Table 2 Reactome gene sets significantly overrepresented among the differentially expressed genes in PBMC from MI patients when compared to controls
No | Reactome set name | Total number of genes in the set | Number of differentially expressed genes (DEGs) | DEGs | FDR |
|---|---|---|---|---|---|
Upregulated genes | |||||
 1 | Immune system | 2663 | 22 | BCL6, BST1, C3AR1, CCR1, CD14, CLEC4D, CLEC6A, CR1, FCGR1A, FCGR1B, FLT3, FPR1, FPR2, GRN, HLA-DQB1, PADI2, PYGL, S100A12, SLC11A1, SOCS3, TLR2, TLR8 | 0.023 |
 2 | Neutrophil degranulation | 480 | 13 | BST1, C3AR1, CD14, CLEC4D, CR1, FPR1, FPR2, GRN, PADI2, PYGL, S100A12, SLC11A1, TLR2 | 0.0035 |
 3 | Cytokine Signaling in immune system | 1055 | 9 | BCL6, CCR1, FCGR1A, FCGR1B, FLT3, FPR1, HLA-DQB1, S100A12, SOCS3 | 0.015 |
 4 | Interferon gamma signaling | 250 | 4 | FCGR1A, FCGR1B, HLA-DQB1, SOCS3 | 0.015 |
 5 | Signaling by non-receptor tyrosine kinases | 70 | 2 | NRG1, SOCS3 | 0.033 |
 6 | Signaling by PTK6 | 70 | 2 | NRG1, SOCS3 | 0.033 |
 7 | PTK6 Activates STAT3 | 7 | 1 | SOCS3 | 0.033 |
 8 | GRB7 events in ERBB2 signaling | 6 | 1 | NRG1 | 0.031 |
 9 | Transport of glycerol from adipocytes to the liver by Aquaporins | 3 | 1 | AQP9 | 0.015 |
Downregulated genes | |||||
 1 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 297 | 6 | KLRB1, KLRC1, KLRD1, KLRF1, KIR2DL1, KIR2DL3 | 0.021 |
 2 | DAP12 signaling | 29 | 4 | KLRC1, KLRC2, KLRC3, KLRD1 | 0.021 |