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Table 1 Oxygen Consumption Rates of the Tissues measured by OROBOROS

From: Proceedings of the 7th Annual United States Army Institute of Surgical Research Summer Internship Program 2019

Respiration (pmol/s/mg)

Liver

Kidney

EDL

Soleus

Control

TH

Control

TH

Control

TH

Control

TH

Endogenous

9.0 ± 0.9

8.2 ± 0.9

21.3 ± 7.1

11.7 ± 7.0

4.8 ± 3.4

2.2 ± 0.8

2.2 ± 0.9

2.0 ± 0.4

Substrate

13.5 ± 1.5

12.7 ± 1.6

39.7 ± 12.5

19.0 ± 2.2

26.2 ± 14.8

15.4 ± 6.7

23.5 ± 5.6

35.9 ± 16.1

ADP

31.8 ± 5.3

22.1 ± 5.1

70.9 ± 23.0

30.8 ± 2.8*

75.3 ± 40.7

42.5 ± 17.5

74.3 ± 22.6

121.3 ± 21.3#

Succinate

64.5 ± 6.9

42.6 ± 5.0*

109.7 ± 39.0

61.0 ± 7.9

98.3 ± 37.7

50.6 ± 14.8

104.2 ± 22.3

152.0 ± 58.6#

Olygomycin

29.6 ± 2.0

24.5 ± 2.9

64.4 ± 16.3

43.1 ± 3.3*

33.8 ± 8.6

16.1 ± 1.9*

36.0 ± 3.6

41.8 ± 8.4#

FCCP

75.5 ± 9.0

44.3 ± 6.5*

95.1 ± 26.1

57.8 ± 2.2

76.3 ± 13.6

39.6 ± 9.9*

85.7 ± 20.5

117.0 ± 53.7#

Ratenone

39.3 ± 5.3

21.8 ± 2.5*

52.7 ± 13.8

31.8 ± 3.7

34.1 ± 8.3

15.6 ± 1.3*

36.6 ± 5.5

47.4 ± 19.0#

Antimycin A

6.5 ± 1.7

6.2 ± 1.2

13.1 ± 1.5

9.2 ± 1.0*

5.1 ± 2.8

3.9 ± 1.9

6.9 ± 3.1

5.1 ± 1.5

  1. *: p < 0.05, significant difference between Control and TH
  2. #: p < 0.05, significant difference between EDL and Soleus in TH