Fig. 5

Association between the age of diagnoses of the index cases and tumor diversity in the respective families with the number of VUS identified in the sample. The upper plot shows how the condition of carrying 3 or more VUS could be determining early cancer onset. The lower plot represents the possible association of the categorical variable “tumor diversity in the family” defined as ‘yes’ when the pedigree harbored more than 3 tumor types. In particular, for the condition of carrying 4, 5 and 6 VUS, the tumor diversity in the pedigrees tends to increase