Fig. 4

Parallel evaluation of the expression profile of programmed death-ligand 1 (PD-L1) on HLA-DR^−/lowCD14⁺ monocytic myeloid-derived suppressor cells (M-MDSCs) and HLA-DR⁺CD14⁺ monocytes/macrophages (MO/MA) in ovarian cancer patients with different clinicopathologic characteristics. a–d The blood (n = 43), ascites (n = 26) and tumour tissue (n = 29) specimens of patients with different stage, grade, Kurman–Shih type and histology were analyzed. The blood samples from healthy women were also examined (n = 15). The frequencies of PD-L1⁺cells are presented as the percentage of the total respective subsets (HLA-DR^−/lowCD14⁺ M-MDSCs and HLA-DR⁺CD14⁺ MO/MA). The horizontal lines are the median values and the whiskers indicate the minimum and maximum values. Each point represents an individual patient. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001