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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition

Fig. 2

FTY720 upregulated hematocytes in Hematological analysis of peripheral blood, recovering symptoms of GvHD mice. a Female Balb/c recipients received 0.5, 1, 3 mg/kg FTY720 per mouse(20 g) beginning at day 0. For allo-HSCT, total BM cells and splenocytes from C57BL/6 were given by tail vein injection. Recipients were given with 690 cGy before injection. The GvHD-induced mice were sacrificed at day 28. b Hematological analysis of peripheral blood at day 28. c Clinical score after BMT, Weight loss in acute GvHD phase, and Survival after BMT. Allogeneic-transplanted animals showed significant increased GvHD score compared with control animals. Animals were regularly scored for five clinical parameters (weight loss, posture, activity, fur and skin) on a scale from 0 to 2. Clinical GvHD score was generated by summation of these five parameters. d Phenotype of syngeneic- and allogeneic-transplanted mice and Spleen at day 28 (the day of sacrifice)

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