Fig. 1
FTY720 suppressed Alloreactive T-cell responses in mice and human with reducing pro-inflammatory cytokines. a, b In the mixed lymphocyte reaction assay, a total of 105 B/c(B6) splenic T cells (responders) were incubated with 105 irradiated B/c(B6) (syngeneic stimulators [Syn]) or B6(B/c) (allogeneic stimulators [Allo]) splenic APCs for 4Â days. c In the mixed lymphocyte reaction assay, human PBMC of healthy volunteer were incubated with another volunteer for 4Â days. d IL-17 and IL-10 concentrations in culture supernatants as determined by ELISA