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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target

Fig. 5

Overexpression of WT1 partially prevents WP1130-induced anti-leukemic activity. a The protein expression of WT1 was measured in THP1 and Kasumi-1 cells, which were transduced with control MSCV-NC or MSCV-WT1. b and c Apoptosis was measured by annexin V/PI staining in THP1 (b) and Kasumi-1 cells (c), which were transduced with control MSCV-NC or MSCV-WT1, followed by the treatment of WP1130 (5.0 µM) for 24 h. d and e Colonies were scored in THP1 and Kasumi-1 cells, which were transduced with MSCV-NC or MSCV-WT1 and then treated by WP1130 (5.0 µM) for 24 h. Shown are the representative pictures showing colonies (left) and statistical analysis of colonies scored (right). Bar represents 50 µm

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