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Table 3 Estimated population parameters for ceftolozane using a modeling approach

From: Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study

Parameter

Model mean

RSE (%)

Fixed effects

 Cl (l/h)

6.15

9.83

 V1 (l)

3.41

36.9

 βSEX/V1

0.998

35.1

 Q (l/h)

9.66

36.1

 V2 (l)

9.92

15.2

BSV (%)

 Cl

23.5

31.4

 V1

2.48

119

 Q

68.7

36.8

 V2

26.6

38.3

 Residual variability (%)

13.9

8.77

  1. BSV between-subject variability, expressed as the coefficient of variation of the associated non-log-transformed parameter, RSE relative standard error
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Journal of Translational Medicine

ISSN: 1479-5876

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