Skip to main content

Table 2 Individual pharmacokinetic parameters determined for the in vivo model using a non-compartmental analysis

From: Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study

Parameter

Ceftolozane 2000 mg

Tazobactam 1000 mg

ECMO

Control

ECMO

Control

AUC (mg/h/l)

375.3 (14.6)

308.6 (34.9)

58.8 (10.7)

42.8 (20.5)

Vz (l)

20.85 (39.9)

31.31 (48.5)

34.93 (44.2)

29.35 (23.6)

Vss (l)

15.33 (33.0)

19.09 (44.9)

13.88 (30.7)

16.99 (16.8)

Cl (l/h)

5.41 (15.7)

6.99 (32.0)

17.13 10.7)

24.98 (19.1)

T1/2 (h)

2.64 (32.0)

3.18 (40.1)

1.40 (42.9)

0.89 (40.5)

  1. Mean (coefficient of variation) of parameters; AUC area under the curve; Vz volume of distribution during pseudo-equilibrium, Vss volume of distribution at steady state, Cl elimination clearance, T1/2 elimination half-life