Skip to main content

Table 2 Individual pharmacokinetic parameters determined for the in vivo model using a non-compartmental analysis

From: Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study

ParameterCeftolozane 2000 mgTazobactam 1000 mg
ECMOControlECMOControl
AUC (mg/h/l)375.3 (14.6)308.6 (34.9)58.8 (10.7)42.8 (20.5)
Vz (l)20.85 (39.9)31.31 (48.5)34.93 (44.2)29.35 (23.6)
Vss (l)15.33 (33.0)19.09 (44.9)13.88 (30.7)16.99 (16.8)
Cl (l/h)5.41 (15.7)6.99 (32.0)17.13 10.7)24.98 (19.1)
T1/2 (h)2.64 (32.0)3.18 (40.1)1.40 (42.9)0.89 (40.5)
  1. Mean (coefficient of variation) of parameters; AUC area under the curve; Vz volume of distribution during pseudo-equilibrium, Vss volume of distribution at steady state, Cl elimination clearance, T1/2 elimination half-life