Fig. 1

DNA methylation analysis in blood samples from patients with congenital scoliosis. a A target region DNA methylation sequencing was performed to screen the differential methylation. Heat map of differential methylation in genes. b Principal component analysis (PCA) in congenital scoliosis samples and healthy samples. c The mean methylation levels and position of the top eight differentially expressed genes. CHST14, carbohydrate sulfotransferase 14; COL14A1, collagen type XIV alpha 1 chain; CREB3L2, cAMP responsive element binding protein 3 like 2; FGF23, fibroblast growth factor 23; INF2, inverted formin 2; KAT6B, lysine acetyltransferase 6B; ADAMTS7, a disintegrin and metalloproteinase with thrombospondin motifs 7; XYLT1, xylosyltransferase 1