Table 2 Baseline characteristics of patients in three independent validation cohorts
Characteristics | Whole cohort | Low risk | High risk | p |
|---|---|---|---|---|
TCGA cohort | (n = 321) | (n = 78) | (n = 243) |  |
Gender | 0.772 | |||
 Male | 204 (63.55) | 48 (61.54) | 156 (64.20) |  |
 Female | 117 (36.45) | 30 (38.46) | 87 (35.80) |  |
Age | 0.995 | |||
 < 65 years | 146 (45.48) | 36 (46.15) | 110 (45.27) |  |
 ≥ 65 years | 175 (54.52) | 42 (53.85) | 133 (54.73) |  |
TNM stagea | 0.253 | |||
 I | 44 (13.71) | 13 (16.67) | 31 (12.76) |  |
 II | 104 (32.40) | 18 (23.08) | 86 (35.39) |  |
 III | 132 (41.12) | 36 (46.15) | 96 (39.51) |  |
 IV | 29 (9.03) | 7 (8.97) | 22 (9.05) |  |
WHO classification | 0.085 | |||
 Intestinal/tubular | 125 (38.94) | 34 (43.59) | 91 (37.45) |  |
 Diffuse | 57 (17.76) | 15 (19.23) | 42 (17.28) |  |
 Mucinous/signet ring cell | 26 (8.10) | 1 (1.28) | 25 (10.29) |  |
 Others | 113 (35.20) | 28 (35.90) | 85 (34.98) |  |
ACRG cohort | (n = 300) | (n = 219) | (n = 81) |  |
Gender | 0.950 | |||
 Male | 199 (66.33) | 146 (66.67) | 53 (65.43) |  |
 Female | 101 (33.67) | 73 (33.33) | 28 (34.57) |  |
Age | 0.999 | |||
 < 65 years | 161 (53.67) | 118 (53.88) | 43 (53.09) |  |
 ≥ 65 years | 139 (46.33) | 101 (46.12) | 38 (46.91) |  |
TNM stage | 0.097 | |||
 I | 30 (10.00) | 27 (12.32) | 3 (3.70) |  |
 II | 97 (32.33) | 73 (33.33) | 24 (29.63) |  |
 III | 96 (32.00) | 67 (30.59) | 29 (35.80) |  |
 IV | 77 (25.67) | 52 (23.74) | 25 (30.86) |  |
Lauren classification | 0.141 | |||
 Diffuse | 135 (45.00) | 91 (41.55) | 44 (54.32) |  |
 Intestinal | 146 (48.67) | 113 (51.60) | 33 (40.74) |  |
 Mixed | 19 (6.33) | 15 (6.84) | 4 (4.93) |  |
CHEM cohort | (n = 136) | (n = 46) | (n = 90) |  |
Gender | 0.709 | |||
 Male | 93 (68.38) | 30 (65.22) | 63 (70.00) |  |
 Female | 43 (31.62) | 16 (34.78) | 27 (30.00) |  |
Age | 0.726 | |||
 < 65 years | 87 (63.97) | 28 (60.87) | 59 (65.56) |  |
 ≥ 65 years | 49 (36.03) | 18 (39.13) | 31 (34.44) |  |
TNM stage | 0.496 | |||
 II | 36 (26.47) | 15 (32.61) | 21 (23.33) |  |
 III | 63 (46.32) | 19 (41.30) | 44 (48.89) |  |
 IV | 37 (27.21) | 12 (26.09) | 25 (27.78) |  |
Lauren classificationa | 0.075 | |||
 Diffuse | 30 (22.06) | 15 (32.61) | 15 (16.67) |  |
 Intestinal | 95 (69.85) | 27 (58.70) | 68 (75.56) |  |
 Mixed | 7 (5.15) | 3 (6.52) | 4 (4.44) |  |