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Table 1 Baseline characteristics of patients in the discovery cohort

From: Development and validation of a hypoxia-immune-based microenvironment gene signature for risk stratification in gastric cancer

Characteristics

Whole cohort (n = 357)

Log-rank p

Low risk (n = 95)

High risk (n = 262)

p

Gender

 

0.203

  

0.427

 Male

242 (67.79)

 

68 (71.58)

174 (66.41)

 

 Female

115 (32.21)

 

27 (28.42)

88 (33.59)

 

Age

 

0.051

  

0.391

 < 65 years

229 (64.15)

 

57 (60.00)

172 (65.65)

 

 ≥ 65 years

128 (35.85)

 

38 (40.00)

90 (34.35)

 

TNM stage

 

< 0.001

  

0.004

 I

21 (5.88)

 

10 (10.53)

11 (4.20)

 

 II

109 (30.53)

 

37 (38.95)

72 (27.48)

 

 III

227 (63.59)

 

48 (50.53)

179 (68.32)

 

t-SNE clustering

 

< 0.001

  

< 0.001

 Cluster1

120 (33.61)

 

12 (12.63)

108 (41.22)

 

 Cluster2

107 (29.97)

 

26 (27.37)

81 (30.92)

 

 Cluster3

130 (36.41)

 

57 (60.00)

73 (27.86)

 

Hypoxia statusa

 

< 0.001

  

< 0.001

 High

120 (33.61)

 

12 (12.63)

108 (41.22)

 

 Low

130 (36.41)

 

57 (60.00)

73 (27.86)

 

Immune statusa

 

0.005

  

< 0.001

 Low

188 (52.66)

 

31 (32.63)

157 (59.92)

 

 High

62 (17.37)

 

38 (40.00)

24 (9.16)

 

Risk group by classifier

 

<  0.001

  

 Low

95 (25.3)

 

95 (100.00)

0 (0.00)

 

 High

262 (74.7)

 

0 (0.00)

262 (100.00)

 
  1. aPatients (n = 107) in t-SNE-derived cluster2 considered as in “moderate hypoxia status” were excluded from the comparison