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Table 1 Baseline characteristics of patients in the discovery cohort

From: Development and validation of a hypoxia-immune-based microenvironment gene signature for risk stratification in gastric cancer

Characteristics Whole cohort (n = 357) Log-rank p Low risk (n = 95) High risk (n = 262) p
Gender   0.203    0.427
 Male 242 (67.79)   68 (71.58) 174 (66.41)  
 Female 115 (32.21)   27 (28.42) 88 (33.59)  
Age   0.051    0.391
 < 65 years 229 (64.15)   57 (60.00) 172 (65.65)  
 ≥ 65 years 128 (35.85)   38 (40.00) 90 (34.35)  
TNM stage   < 0.001    0.004
 I 21 (5.88)   10 (10.53) 11 (4.20)  
 II 109 (30.53)   37 (38.95) 72 (27.48)  
 III 227 (63.59)   48 (50.53) 179 (68.32)  
t-SNE clustering   < 0.001    < 0.001
 Cluster1 120 (33.61)   12 (12.63) 108 (41.22)  
 Cluster2 107 (29.97)   26 (27.37) 81 (30.92)  
 Cluster3 130 (36.41)   57 (60.00) 73 (27.86)  
Hypoxia statusa   < 0.001    < 0.001
 High 120 (33.61)   12 (12.63) 108 (41.22)  
 Low 130 (36.41)   57 (60.00) 73 (27.86)  
Immune statusa   0.005    < 0.001
 Low 188 (52.66)   31 (32.63) 157 (59.92)  
 High 62 (17.37)   38 (40.00) 24 (9.16)  
Risk group by classifier   <  0.001   
 Low 95 (25.3)   95 (100.00) 0 (0.00)  
 High 262 (74.7)   0 (0.00) 262 (100.00)  
  1. aPatients (n = 107) in t-SNE-derived cluster2 considered as in “moderate hypoxia status” were excluded from the comparison