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Table 4 The comparisons of CSF laboratory examinations across mNGS subgroups

From: Clinical application and evaluation of metagenomic next-generation sequencing in suspected adult central nervous system infection

 mNGS positive/Case consistent (a)mNGS positive/Case inconsistent (b)mNGS negative/Case inconsistent (c)mNGS negative/Case consistent (d)p value among all groups (Mann–Whitney test)p value between group a and c (Mann–Whitney test)p value between group a and d (Mann–Whitney test)
Suspected CNS infections (a = 61; b = 7; c = 98; d = 70)
 CSF WBC,*106/L (Median(Range))130 (1–26,000)60 (1–110)68 (1–1630)7 (0–340)0.001*0.002*< 0.0001*
 CSF protein, mg/L (Median(Range))1741.0 (209.0–15,000.0)839.5 (208.0–5477.0)1351.0 (33.0–15,000.0)686.0 (208.0–13,223.0)0.0650.002*< 0.0001*
 CSF/serum glucose ratio (Mean (Range))0.36 (0.06–0.71)0.37 (0.24–0.5)0.42 (0.10–0.75)0.60 (0.13–1.19)0.023*0.003*< 0.0001*
 CSF Cl, mmol/L (Mean(Range))115.65 (97.00–143.00)119.50 (104.00–130.00)116.81 (92.00–130.00)118.52 (96.00–132.00)0.8450.1100.29
 CSF pressure, mmH2O (Mean(Range))198.16 (50.00–300.00)159.40 (70.00–300.00)194.19 (88.00–300.00)185.47 (80.00–300.00)0.5980.7940.24
Bacteria (a = 43; b = 5; c = 56; d = 126)
 CSF WBC, *106/L (Median(Range))138 (1–26,000)40 (1–110)68 (4–1630)20 (0–730)0.000 *0.029*< 0.0001*
 CSF protein, mg/L (Median (Range))1845.5 (209.0–14,224.0)1112.0 (208.0–2499.0)1100.0 (33.0–15,000.0)867.0 (208.0–15,000.0)0.1180.1150.000*
 CSF/serum glucose ratio (Mean(Range))0.29 (0.06–0.52)0.42 (0.31–0.55)0.41 (0.19–0.75)0.53 (0.10–1.19)0.0850.001*< 0.0001*
 CSF Cl, mmol/L (Mean(Range))115.32 (98.00–131.00)117.20 (104.00–122.00)114.96 (92.00–126.00)118.49 (96.00–143.00)0.6800.6770.076
 CSF pressure, mmH2O (Mean(Range))212.68 (92.00–300.00)135.00 (70.00–215.00)192.48 (88.00–300.00)188.01 (50.00–300.00)0.1530.2860.114
Virus (a = 9; b = 2; c = 32; d = 187)
 CSF WBC,*106/L (Median(Range))161 (45–300)121 (2–242)35 (1–570)46 (0–26000)0.7240.019*0.116
 CSF protein, mg/L (Median(Range))1657.0 (662.0–6459.0)1036.5 (671.0–1456.0)937.5 (208.0–6741.0)1066.0 (33.0–15,000.0)0.1900.0120.125
 CSF/serum glucose ratio (Mean(Range))0.44 (0.36–0.59)0.50 (0.39–0.62)0.48 (0.31–0.73)0.45 (0.06–1.19)0.9940.2990.539
 CSF Cl, mmol/L (Mean(Range))117.57 (100.00–131.00)123.50 (113.00–134.00)119.61 (104.00–143.00)116.49 (92.00–132.00)0.7850.5790.527
 CSF pressure, mmH2O (Mean(Range))194.17 (100.00–230.00)140.00 (85.00–195.00)191.35 (100.00–300.00)192.28 (50.00–300.00)0.7720.9350.812
Fungi (a = 8; b = 0; c = 3; d = 219)
 CSF WBC, *106/L (Median(Range))115 (70–730)N/A2 (2–15)44 (0–26,000)0.9020.238< 0.0001*
 CSF protein, mg/L (Median (Range))1122.5 (520.0–15,000.0)1480.0 (1401.0–1484.0)1060.0 (33.0–7098.0)0.1450.5480.377
 CSF/serum glucose ratio (Mean(Range))0.33 (0.16–0.52)0.40 (0.24–0.52)0.46 (0.06–1.19)0.7740.5480.093
 CSF Cl, mmol/L (Mean(Range))111.83 (97.00–122.00)122.33 (116.00–130.00)117.18 (92.00–143.00)0.6840.3810.461
 CSF pressure, mmH2O (Mean(Range))170.00 (50.00–300.00)146.67 (130.00–160.00)193.15 (70.00–300.00)0.4030.7860.611
Parasite (a = 2; b = 0; c = 1; d = 227)
 CSF WBC, *106/L (Median(Range))34 (9–58)N/A0 (N/A)50 (0–26,000)0.947N/A0.686
 CSF protein, mg/L (Median(Range))959.0 (506.0–1412.0)181.0 (N/A)1079.5 (33.0–15,000.0)0.6820.706
 CSF/serum glucose ratio (Mean(Range))0.36 (0.29–0.42)0.65 (N/A)0.46 (0.06–1.19)0.8790.458
 CSF Cl, mmol/L (Mean(Range))119.50 (111.00–128.00)127.00 (N/A)117.04 (92.00–143.00)0.8430.703
 CSF pressure, mmH2O (Mean(Range))222.50 (150.00–295.00)135.00 (N/A)191.13 (50.00–300.00)0.5880.697
  1. Statistics analysis: Mann–Whitney test as listed in Table 4
  2. *p value < 0.05