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Table 4 The comparisons of CSF laboratory examinations across mNGS subgroups

From: Clinical application and evaluation of metagenomic next-generation sequencing in suspected adult central nervous system infection

 

mNGS positive/Case consistent (a)

mNGS positive/Case inconsistent (b)

mNGS negative/Case inconsistent (c)

mNGS negative/Case consistent (d)

p value among all groups (Mann–Whitney test)

p value between group a and c (Mann–Whitney test)

p value between group a and d (Mann–Whitney test)

Suspected CNS infections (a = 61; b = 7; c = 98; d = 70)

 CSF WBC,*106/L (Median(Range))

130 (1–26,000)

60 (1–110)

68 (1–1630)

7 (0–340)

0.001*

0.002*

< 0.0001*

 CSF protein, mg/L (Median(Range))

1741.0 (209.0–15,000.0)

839.5 (208.0–5477.0)

1351.0 (33.0–15,000.0)

686.0 (208.0–13,223.0)

0.065

0.002*

< 0.0001*

 CSF/serum glucose ratio (Mean (Range))

0.36 (0.06–0.71)

0.37 (0.24–0.5)

0.42 (0.10–0.75)

0.60 (0.13–1.19)

0.023*

0.003*

< 0.0001*

 CSF Cl, mmol/L (Mean(Range))

115.65 (97.00–143.00)

119.50 (104.00–130.00)

116.81 (92.00–130.00)

118.52 (96.00–132.00)

0.845

0.110

0.29

 CSF pressure, mmH2O (Mean(Range))

198.16 (50.00–300.00)

159.40 (70.00–300.00)

194.19 (88.00–300.00)

185.47 (80.00–300.00)

0.598

0.794

0.24

Bacteria (a = 43; b = 5; c = 56; d = 126)

 CSF WBC, *106/L (Median(Range))

138 (1–26,000)

40 (1–110)

68 (4–1630)

20 (0–730)

0.000 *

0.029*

< 0.0001*

 CSF protein, mg/L (Median (Range))

1845.5 (209.0–14,224.0)

1112.0 (208.0–2499.0)

1100.0 (33.0–15,000.0)

867.0 (208.0–15,000.0)

0.118

0.115

0.000*

 CSF/serum glucose ratio (Mean(Range))

0.29 (0.06–0.52)

0.42 (0.31–0.55)

0.41 (0.19–0.75)

0.53 (0.10–1.19)

0.085

0.001*

< 0.0001*

 CSF Cl, mmol/L (Mean(Range))

115.32 (98.00–131.00)

117.20 (104.00–122.00)

114.96 (92.00–126.00)

118.49 (96.00–143.00)

0.680

0.677

0.076

 CSF pressure, mmH2O (Mean(Range))

212.68 (92.00–300.00)

135.00 (70.00–215.00)

192.48 (88.00–300.00)

188.01 (50.00–300.00)

0.153

0.286

0.114

Virus (a = 9; b = 2; c = 32; d = 187)

 CSF WBC,*106/L (Median(Range))

161 (45–300)

121 (2–242)

35 (1–570)

46 (0–26000)

0.724

0.019*

0.116

 CSF protein, mg/L (Median(Range))

1657.0 (662.0–6459.0)

1036.5 (671.0–1456.0)

937.5 (208.0–6741.0)

1066.0 (33.0–15,000.0)

0.190

0.012

0.125

 CSF/serum glucose ratio (Mean(Range))

0.44 (0.36–0.59)

0.50 (0.39–0.62)

0.48 (0.31–0.73)

0.45 (0.06–1.19)

0.994

0.299

0.539

 CSF Cl, mmol/L (Mean(Range))

117.57 (100.00–131.00)

123.50 (113.00–134.00)

119.61 (104.00–143.00)

116.49 (92.00–132.00)

0.785

0.579

0.527

 CSF pressure, mmH2O (Mean(Range))

194.17 (100.00–230.00)

140.00 (85.00–195.00)

191.35 (100.00–300.00)

192.28 (50.00–300.00)

0.772

0.935

0.812

Fungi (a = 8; b = 0; c = 3; d = 219)

 CSF WBC, *106/L (Median(Range))

115 (70–730)

N/A

2 (2–15)

44 (0–26,000)

0.902

0.238

< 0.0001*

 CSF protein, mg/L (Median (Range))

1122.5 (520.0–15,000.0)

1480.0 (1401.0–1484.0)

1060.0 (33.0–7098.0)

0.145

0.548

0.377

 CSF/serum glucose ratio (Mean(Range))

0.33 (0.16–0.52)

0.40 (0.24–0.52)

0.46 (0.06–1.19)

0.774

0.548

0.093

 CSF Cl, mmol/L (Mean(Range))

111.83 (97.00–122.00)

122.33 (116.00–130.00)

117.18 (92.00–143.00)

0.684

0.381

0.461

 CSF pressure, mmH2O (Mean(Range))

170.00 (50.00–300.00)

146.67 (130.00–160.00)

193.15 (70.00–300.00)

0.403

0.786

0.611

Parasite (a = 2; b = 0; c = 1; d = 227)

 CSF WBC, *106/L (Median(Range))

34 (9–58)

N/A

0 (N/A)

50 (0–26,000)

0.947

N/A

0.686

 CSF protein, mg/L (Median(Range))

959.0 (506.0–1412.0)

181.0 (N/A)

1079.5 (33.0–15,000.0)

0.682

0.706

 CSF/serum glucose ratio (Mean(Range))

0.36 (0.29–0.42)

0.65 (N/A)

0.46 (0.06–1.19)

0.879

0.458

 CSF Cl, mmol/L (Mean(Range))

119.50 (111.00–128.00)

127.00 (N/A)

117.04 (92.00–143.00)

0.843

0.703

 CSF pressure, mmH2O (Mean(Range))

222.50 (150.00–295.00)

135.00 (N/A)

191.13 (50.00–300.00)

0.588

0.697

  1. Statistics analysis: Mann–Whitney test as listed in Table 4
  2. *p value < 0.05