TY - JOUR AU - Wang, Xu AU - Zhou, Wenjuan AU - Li, Xian AU - Ren, Jun AU - Ji, Guangyu AU - Du, Jingyi AU - Tian, Wenyu AU - Liu, Qian AU - Hao, Aijun PY - 2020 DA - 2020/05/14 TI - Graphene oxide suppresses the growth and malignancy of glioblastoma stem cell-like spheroids via epigenetic mechanisms JO - Journal of Translational Medicine SP - 200 VL - 18 IS - 1 AB - Glioblastoma stem-like cells (GSCs) are hypothesized to contribute to self-renewal and therapeutic resistance in glioblastoma multiforme (GBM) tumors. Constituting only a small percentage of cancer cells, GSCs possess “stem-like”, tumor-initiating properties and display resistance to irradiation and chemotherapy. Thus, novel approaches that can be used to suppress GSCs are urgently needed. A new carbon material—graphene oxide (GO), has been reported to show potential for use in tumor therapy. However, the exact effect of GO on GSCs and the inherent mechanism underlying its action are not clear. In this study, we aimed to investigate the usefulness of GO to inhibit the growth and promote the differentiation of GSCs, so as to suppress the malignancy of GBM. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-020-02359-z DO - 10.1186/s12967-020-02359-z ID - Wang2020 ER -