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Table 3 Major biochemical pathways associated with blood metabolite differences in CFS/ME/SEID patients

From: A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID)

Author and yearMajor biochemical pathways
Germain et al. (2020) [21]Energy metabolism
    Amino acid metabolism
Lipids
    Fatty acid metabolism
    Androgenic steroids
    Corticosteroids
    Secondary bile acid metabolism
Xenobiotics
    Chemical
    Food component/plant
Germain et al. (2018) [22]Energy metabolism
    Tricarboxylic acid cycle
    Amino acid metabolism
Nucleotides
    Pyrimidine metabolism
    Purine metabolism
Peptides
    Protein degradation
Cofactors and vitamins
    Haeme
    Vitamin E pathway
Nagy-Szakal et al. (2018) [29]Energy metabolism
    Transport of activated residues between cellular organelles
Lipid metabolism
    Cell membrane phospholipid
Germain et al. (2017) [23]Energy metabolism
    ATP and ADP perturbations
    Amino acid metabolism
    Pentose phosphate pathway
    Ascorbate and aldarate metabolism
    Glycolysis pathway
    Gluconeogenesis pathway
    Citrate cycle
    Starch and sucrose metabolism
    Galactose metabolism
    Pyruvate metabolism
Nucleotides
    Purine metabolism
Lipids metabolism
    Biological membrane composition
Yamano et al. (2016) [24]Energy metabolism
    Tricarboxylic acid cycle
    Urea cycle
Fluge et al. (2016) [25]Energy metabolism
    Amino acid metabolism
Naviaux et al. (2016) [30]Energy metabolism
    Redox regulation
    NADPH availability
Armstrong et al. (2015) [26]Energy metabolism
    Glycolysis pathway
    amino acid metabolism
Armstrong et al. (2012) [18]Energy metabolism
    Amino acid metabolism (urea pathway)
    Nitrogen metabolism (urea pathway)
Jones et al. (2005) [27]Energy metabolism
    Amino acid metabolism