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Table 3 Major biochemical pathways associated with blood metabolite differences in CFS/ME/SEID patients

From: A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID)

Author and year

Major biochemical pathways

Germain et al. (2020) [21]

Energy metabolism

    Amino acid metabolism

Lipids

    Fatty acid metabolism

    Androgenic steroids

    Corticosteroids

    Secondary bile acid metabolism

Xenobiotics

    Chemical

    Food component/plant

Germain et al. (2018) [22]

Energy metabolism

    Tricarboxylic acid cycle

    Amino acid metabolism

Nucleotides

    Pyrimidine metabolism

    Purine metabolism

Peptides

    Protein degradation

Cofactors and vitamins

    Haeme

    Vitamin E pathway

Nagy-Szakal et al. (2018) [29]

Energy metabolism

    Transport of activated residues between cellular organelles

Lipid metabolism

    Cell membrane phospholipid

Germain et al. (2017) [23]

Energy metabolism

    ATP and ADP perturbations

    Amino acid metabolism

    Pentose phosphate pathway

    Ascorbate and aldarate metabolism

    Glycolysis pathway

    Gluconeogenesis pathway

    Citrate cycle

    Starch and sucrose metabolism

    Galactose metabolism

    Pyruvate metabolism

Nucleotides

    Purine metabolism

Lipids metabolism

    Biological membrane composition

Yamano et al. (2016) [24]

Energy metabolism

    Tricarboxylic acid cycle

    Urea cycle

Fluge et al. (2016) [25]

Energy metabolism

    Amino acid metabolism

Naviaux et al. (2016) [30]

Energy metabolism

    Redox regulation

    NADPH availability

Armstrong et al. (2015) [26]

Energy metabolism

    Glycolysis pathway

    amino acid metabolism

Armstrong et al. (2012) [18]

Energy metabolism

    Amino acid metabolism (urea pathway)

    Nitrogen metabolism (urea pathway)

Jones et al. (2005) [27]

Energy metabolism

    Amino acid metabolism