Table 3 Major biochemical pathways associated with blood metabolite differences in CFS/ME/SEID patients
| Author and year | Major biochemical pathways |
|---|---|
| Germain et al. (2020) [21] | Energy metabolism Amino acid metabolism Lipids Fatty acid metabolism Androgenic steroids Corticosteroids Secondary bile acid metabolism Xenobiotics Chemical Food component/plant |
| Germain et al. (2018) [22] | Energy metabolism Tricarboxylic acid cycle Amino acid metabolism Nucleotides Pyrimidine metabolism Purine metabolism Peptides Protein degradation Cofactors and vitamins Haeme Vitamin E pathway |
| Nagy-Szakal et al. (2018) [29] | Energy metabolism Transport of activated residues between cellular organelles Lipid metabolism Cell membrane phospholipid |
| Germain et al. (2017) [23] | Energy metabolism ATP and ADP perturbations Amino acid metabolism Pentose phosphate pathway Ascorbate and aldarate metabolism Glycolysis pathway Gluconeogenesis pathway Citrate cycle Starch and sucrose metabolism Galactose metabolism Pyruvate metabolism Nucleotides Purine metabolism Lipids metabolism Biological membrane composition |
| Yamano et al. (2016) [24] | Energy metabolism Tricarboxylic acid cycle Urea cycle |
| Fluge et al. (2016) [25] | Energy metabolism Amino acid metabolism |
| Naviaux et al. (2016) [30] | Energy metabolism Redox regulation NADPH availability |
| Armstrong et al. (2015) [26] | Energy metabolism Glycolysis pathway amino acid metabolism |
| Armstrong et al. (2012) [18] | Energy metabolism Amino acid metabolism (urea pathway) Nitrogen metabolism (urea pathway) |
| Jones et al. (2005) [27] | Energy metabolism Amino acid metabolism |