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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma

Fig. 4

Surgery coupled with systemic treatment to reeducate macrophages yields survival benefits BALB/c mice were implanted with 3 × 105 cells in the left tibia (n = 13–15 mice/group). One week after tumor implantation mice assigned to surgical groups underwent surgical excision of primary tumor bearing limb as in Fig. 1. Mice assigned to gefitinib treatment were started on gefitinib-impregnated chow (100 mg/kg/day) 2 days prior to surgical excision (5 days after tumor implantation). Gefitinib treatment was continued for the duration of the experiment. Mice were sacrificed upon meeting euthanasia criteria as previously described. Data analyzed using Log-rank (Mantel–Cox) test,*p < 0.05

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