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Table 3 The association of rs12696304 variants with primary GN/CKD risk

From: The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females

 

Controls

(M + F)

Patients

(M + F)

Odds ratio

(95% CI)

P

value

Controls

(M only)

Patients

(M only)

Odds ratio

(95% CI)

P

value

Controls

(F only)

Patients

(F only)

Odds ratio

(95% CI)

P

value

rs12696304(N)

515 (100%)

243 (100%)

  

289 (100%)

133 (100%)

  

226(100%)

110(100%)

  

CC

56 (10.9)

13 (5.3)

1.0 (ref.)

 

32 (11.1)

9 (6.7)

1.0 (ref.)

 

24 (10.6)

4 (3.6)

1.0 (ref.)

 

GC

223 (43.3)

89 (36.6)

1.719 (0.896–3.298)

0.135

119 (41.2)

49 (36.8)

1.464 (0.651–3.294)

0.465

104 (46.0)

40 (36.4)

2.308 (0.753–7.070)

0.207

GG

236 (45.8)

141 (58.1)

2.574 (1.359–4.873)

0.004

138 (47.7)

75 (56.5)

1.932 (0.876–4.263)

0.141

98 (43.4)

66 (60.0)

4.041(1.340–12.181)

0.015

CC + GC

279 (54.2)

102 (41.9)

1.0 (ref.)

 

151 (52.3)

58 (43.5)

1.0 (ref.)

 

128 (56.6)

44 (40.0)

1.0 (ref.)

 

GG

236 (45.8)

141 (58.1)

1.634 (1.201–2.234)

0.002

138 (47.7)

75 (56.5)

1.415 (0.936–2.139)

0.122

98 (43.4)

66 (60.0)

1.959 (1.233–3.114)

0.006

C

335 (32.5)

115 (23.7)

  

183 (31.7)

67 (25.2)

1.0 (ref.)

 

152 (33.6)

48

1.0 (ref.)

 

G

695 (67.5)

371 (76.3)

1.555 (1.215–1.990)

0.0001

395 (68.3)

199 (74.8)

1.376 (0.992–1.910)

0.067

300 (66.4)

172

1.816 (1.248–2.641)

0.002

rs2736100 (N)

515 (100%)

237 (100%)

  

289 (100%)

129 (100%)

  

226 (100%)

108 (100%)

  

AA

158 (30.7)

66 (27.9)

1.0 (ref.)

 

93 (32.2)

34 (26.4)

1.0 (ref.)

 

65 (28.8)

32 (29.6)

1.0 (ref.)

 

AC

257 (49.9)

116 (48.9)

1.081 (0.753–1.551)

0.743

136 (47.1)

67 (51.9)

1.348 (0.826–2.199)

0.283

121 (53.5)

49 (45.4)

0.823 (0.481–1.409)

0.566

CC

100 (19.4)

55 (23.2)

1.317 (0.851–2.038)

0.261

60 (20.7)

28 (21.7)

1.276 (0.703–2.317)

0.516

40 (17.7)

27 (25.0)

1.371 (0.719–2.616)

0.428

A

573 (55.6)

248 (52.3)

1.0 (ref.)

 

322(55.7)

135 (52.3)

1.0 (ref.)

 

251(55.5)

113 (52.3)

1.0 (ref.)

 

C

457 (44.4)

226 (47.7)

1.143 (0.919–1.421)

0.253

256(44.3)

123 (47.7)

1.146 (0.854–1.538)

0.405

201(44.5)

103 (47.7)

1.138 (0.822–1.576)

0.485

  1. GN Glomerulonephritis, CKD chronic kidney disease, M male, F female, CI confidence interval; italic P value: statistically significant