Skip to main content

Table 3 The association of rs12696304 variants with primary GN/CKD risk

From: The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females

 Controls
(M + F)
Patients
(M + F)
Odds ratio
(95% CI)
P
value
Controls
(M only)
Patients
(M only)
Odds ratio
(95% CI)
P
value
Controls
(F only)
Patients
(F only)
Odds ratio
(95% CI)
P
value
rs12696304(N)515 (100%)243 (100%)  289 (100%)133 (100%)  226(100%)110(100%)  
CC56 (10.9)13 (5.3)1.0 (ref.) 32 (11.1)9 (6.7)1.0 (ref.) 24 (10.6)4 (3.6)1.0 (ref.) 
GC223 (43.3)89 (36.6)1.719 (0.896–3.298)0.135119 (41.2)49 (36.8)1.464 (0.651–3.294)0.465104 (46.0)40 (36.4)2.308 (0.753–7.070)0.207
GG236 (45.8)141 (58.1)2.574 (1.359–4.873)0.004138 (47.7)75 (56.5)1.932 (0.876–4.263)0.14198 (43.4)66 (60.0)4.041(1.340–12.181)0.015
CC + GC279 (54.2)102 (41.9)1.0 (ref.) 151 (52.3)58 (43.5)1.0 (ref.) 128 (56.6)44 (40.0)1.0 (ref.) 
GG236 (45.8)141 (58.1)1.634 (1.201–2.234)0.002138 (47.7)75 (56.5)1.415 (0.936–2.139)0.12298 (43.4)66 (60.0)1.959 (1.233–3.114)0.006
C335 (32.5)115 (23.7)  183 (31.7)67 (25.2)1.0 (ref.) 152 (33.6)481.0 (ref.) 
G695 (67.5)371 (76.3)1.555 (1.215–1.990)0.0001395 (68.3)199 (74.8)1.376 (0.992–1.910)0.067300 (66.4)1721.816 (1.248–2.641)0.002
rs2736100 (N)515 (100%)237 (100%)  289 (100%)129 (100%)  226 (100%)108 (100%)  
AA158 (30.7)66 (27.9)1.0 (ref.) 93 (32.2)34 (26.4)1.0 (ref.) 65 (28.8)32 (29.6)1.0 (ref.) 
AC257 (49.9)116 (48.9)1.081 (0.753–1.551)0.743136 (47.1)67 (51.9)1.348 (0.826–2.199)0.283121 (53.5)49 (45.4)0.823 (0.481–1.409)0.566
CC100 (19.4)55 (23.2)1.317 (0.851–2.038)0.26160 (20.7)28 (21.7)1.276 (0.703–2.317)0.51640 (17.7)27 (25.0)1.371 (0.719–2.616)0.428
A573 (55.6)248 (52.3)1.0 (ref.) 322(55.7)135 (52.3)1.0 (ref.) 251(55.5)113 (52.3)1.0 (ref.) 
C457 (44.4)226 (47.7)1.143 (0.919–1.421)0.253256(44.3)123 (47.7)1.146 (0.854–1.538)0.405201(44.5)103 (47.7)1.138 (0.822–1.576)0.485
  1. GN Glomerulonephritis, CKD chronic kidney disease, M male, F female, CI confidence interval; italic P value: statistically significant