Controls (M + F) | Patients (M + F) | Odds ratio (95% CI) | P value | Controls (M only) | Patients (M only) | Odds ratio (95% CI) | P value | Controls (F only) | Patients (F only) | Odds ratio (95% CI) | P value | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
rs12696304(N) | 515 (100%) | 243 (100%) | 289 (100%) | 133 (100%) | 226(100%) | 110(100%) | ||||||
CC | 56 (10.9) | 13 (5.3) | 1.0 (ref.) | 32 (11.1) | 9 (6.7) | 1.0 (ref.) | 24 (10.6) | 4 (3.6) | 1.0 (ref.) | |||
GC | 223 (43.3) | 89 (36.6) | 1.719 (0.896–3.298) | 0.135 | 119 (41.2) | 49 (36.8) | 1.464 (0.651–3.294) | 0.465 | 104 (46.0) | 40 (36.4) | 2.308 (0.753–7.070) | 0.207 |
GG | 236 (45.8) | 141 (58.1) | 2.574 (1.359–4.873) | 0.004 | 138 (47.7) | 75 (56.5) | 1.932 (0.876–4.263) | 0.141 | 98 (43.4) | 66 (60.0) | 4.041(1.340–12.181) | 0.015 |
CC + GC | 279 (54.2) | 102 (41.9) | 1.0 (ref.) | 151 (52.3) | 58 (43.5) | 1.0 (ref.) | 128 (56.6) | 44 (40.0) | 1.0 (ref.) | |||
GG | 236 (45.8) | 141 (58.1) | 1.634 (1.201–2.234) | 0.002 | 138 (47.7) | 75 (56.5) | 1.415 (0.936–2.139) | 0.122 | 98 (43.4) | 66 (60.0) | 1.959 (1.233–3.114) | 0.006 |
C | 335 (32.5) | 115 (23.7) | 183 (31.7) | 67 (25.2) | 1.0 (ref.) | 152 (33.6) | 48 | 1.0 (ref.) | ||||
G | 695 (67.5) | 371 (76.3) | 1.555 (1.215–1.990) | 0.0001 | 395 (68.3) | 199 (74.8) | 1.376 (0.992–1.910) | 0.067 | 300 (66.4) | 172 | 1.816 (1.248–2.641) | 0.002 |
rs2736100 (N) | 515 (100%) | 237 (100%) | 289 (100%) | 129 (100%) | 226 (100%) | 108 (100%) | ||||||
AA | 158 (30.7) | 66 (27.9) | 1.0 (ref.) | 93 (32.2) | 34 (26.4) | 1.0 (ref.) | 65 (28.8) | 32 (29.6) | 1.0 (ref.) | |||
AC | 257 (49.9) | 116 (48.9) | 1.081 (0.753–1.551) | 0.743 | 136 (47.1) | 67 (51.9) | 1.348 (0.826–2.199) | 0.283 | 121 (53.5) | 49 (45.4) | 0.823 (0.481–1.409) | 0.566 |
CC | 100 (19.4) | 55 (23.2) | 1.317 (0.851–2.038) | 0.261 | 60 (20.7) | 28 (21.7) | 1.276 (0.703–2.317) | 0.516 | 40 (17.7) | 27 (25.0) | 1.371 (0.719–2.616) | 0.428 |
A | 573 (55.6) | 248 (52.3) | 1.0 (ref.) | 322(55.7) | 135 (52.3) | 1.0 (ref.) | 251(55.5) | 113 (52.3) | 1.0 (ref.) | |||
C | 457 (44.4) | 226 (47.7) | 1.143 (0.919–1.421) | 0.253 | 256(44.3) | 123 (47.7) | 1.146 (0.854–1.538) | 0.405 | 201(44.5) | 103 (47.7) | 1.138 (0.822–1.576) | 0.485 |