Table 2 Genotyping results of rs12696304 and rs2736100 in controls and patients with GN/CKD/ESRD
Controls (M + F) | Patients (M + F) | Odds ratio (95% CI) | P value | Controls (M only) | Patients (M only) | Odds ratio (95% CI) | P value | Controls (F only) | Patients (F only) | Odds ratio (95% CI) | P value | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs12696304 (N) | 515 (100%) | 759 (100%) | 289 (100%) | 434 (100%) | 226(100%) | 326(100%) | ||||||
CC | 56 (10.9) | 64 (8.4) | 1.0 (ref.) | 32 (11.1) | 40 (9.2) | 1.0 (ref.) | 24 (10.6) | 24 (7.4) | 1.0 (ref.) | |||
GC | 223 (43.3) | 275 (36.2) | 1.079 (0.723–1.609) | 0.709 | 119 (41.2) | 157 (36.3) | 1.055 (0.626–1.779) | 0.840 | 104 (46.0) | 118 (36.2) | 1.135 (0.608–2.118) | 0.692 |
GG | 236 (45.8) | 420 (55.4) | 1.557 (1.052–2.306) | 0.026 | 138 (47.7) | 236 (54.5) | 1.368 (0.821–2.279) | 0.227 | 98 (43.4) | 184 (56.4) | 1.878 (1.013–3.478) | 0.043 |
CC + GC | 279 (54.2) | 339 (44.6) | 1.0 (ref.) | 151 (52.3) | 197 (45.5) | 1.0 (ref.) | 128 (56.6) | 142 (43.6) | 1.0 (ref.) | |||
GG | 236 (45.8) | 420 (55.4) | 1.465 (1.170–1.834) | 0.001 | 138 (47.7) | 236 (54.5) | 1.311 (0.973–1.767) | 0.089 | 98 (43.4) | 184 (56.4) | 1.692 (1.202–2.383) | 0.003 |
C | 335 (32.5) | 403 (26.5) | 1.0 (ref.) | 183 (31.7) | 237 (27.4) | 1.0 (ref.) | 152 (33.6) | 166 (25.5) | 1.0 (ref.) | |||
G | 695 (67.5) | 1115 (73.5) | 1.334 (1.122–1.586) | 0.001 | 395 (68.3) | 629 (72.6) | 1.230 (0.977–1.548) | 0.078 | 300 (66.4) | 486 (74.5) | 1.483 (1.140–1.929) | 0.003 |
rs2736100 (N) | 515 (100%) | 757 (100%) | 289 (100%) | 426 (100%) | 226 (100%) | 331 (100%) | ||||||
AA | 158 (30.7) | 222 (29.3) | 1.0 (ref.) | 93 (32.2) | 138 (32.4) | 1.0 (ref.) | 65 (28.8) | 84 (25.4) | 1.0 (ref.) | |||
AC | 257 (49.9) | 364 (48.1) | 1.008 (0.778–1.306) | 0.952 | 136 (47.1) | 201 (47.2) | 0.996 (0.708–1.401) | 0.982 | 121 (53.5) | 163 (49.2) | 1.042 (0.699–1.555) | 0.839 |
CC | 100 (19.4) | 171 (22.6) | 1.217 (0.884–1.676) | 0.229 | 60 (20.7) | 87 (20.4) | 0.977 (0.641–1.489) | 0.914 | 40 (17.7) | 84 (25.4) | 1.625 (0.989–2.670) | 0.055 |
A | 573 (55.6) | 808 (53.4) | 1.0 (ref.) | 322 (55.7) | 477 (56.0) | 1.0 (ref.) | 251 (55.5) | 331 (50.0) | 1.0 (ref.) | |||
C | 457 (44.4) | 706 (46.6) | 1.098 (0.934–1.284) | 0.261 | 256 (44.3) | 375 (44.0) | 0.989 (0.799–1.223) | 0.918 | 201 (44.5) | 331 (50.0) | 1.249 (0.982–1.588) | 0.070 |