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Table 2 Genotyping results of rs12696304 and rs2736100 in controls and patients with GN/CKD/ESRD

From: The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females

 Controls (M + F)Patients
(M + F)
Odds ratio
(95% CI)
P valueControls (M only)Patients
(M only)
Odds ratio
(95% CI)
P valueControls
(F only)
Patients
(F only)
Odds ratio
(95% CI)
P
value
rs12696304 (N)515 (100%)759 (100%)  289 (100%)434 (100%)  226(100%)326(100%)  
CC56 (10.9)64 (8.4)1.0 (ref.) 32 (11.1)40 (9.2)1.0 (ref.) 24 (10.6)24 (7.4)1.0 (ref.) 
GC223 (43.3)275 (36.2)1.079 (0.723–1.609)0.709119 (41.2)157 (36.3)1.055 (0.626–1.779)0.840104 (46.0)118 (36.2)1.135 (0.608–2.118)0.692
GG236 (45.8)420 (55.4)1.557 (1.052–2.306)0.026138 (47.7)236 (54.5)1.368 (0.821–2.279)0.22798 (43.4)184 (56.4)1.878 (1.013–3.478)0.043
CC + GC279 (54.2)339 (44.6)1.0 (ref.) 151 (52.3)197 (45.5)1.0 (ref.) 128 (56.6)142 (43.6)1.0 (ref.) 
GG236 (45.8)420 (55.4)1.465 (1.170–1.834)0.001138 (47.7)236 (54.5)1.311 (0.973–1.767)0.08998 (43.4)184 (56.4)1.692 (1.202–2.383)0.003
C335 (32.5)403 (26.5)1.0 (ref.) 183 (31.7)237 (27.4)1.0 (ref.) 152 (33.6)166 (25.5)1.0 (ref.) 
G695 (67.5)1115 (73.5)1.334 (1.122–1.586)0.001395 (68.3)629 (72.6)1.230 (0.977–1.548)0.078300 (66.4)486 (74.5)1.483 (1.140–1.929)0.003
rs2736100 (N)515 (100%)757 (100%)  289 (100%)426 (100%)  226 (100%)331 (100%)  
AA158 (30.7)222 (29.3)1.0 (ref.) 93 (32.2)138 (32.4)1.0 (ref.) 65 (28.8)84 (25.4)1.0 (ref.) 
AC257 (49.9)364 (48.1)1.008 (0.778–1.306)0.952136 (47.1)201 (47.2)0.996 (0.708–1.401)0.982121 (53.5)163 (49.2)1.042 (0.699–1.555)0.839
CC100 (19.4)171 (22.6)1.217 (0.884–1.676)0.22960 (20.7)87 (20.4)0.977 (0.641–1.489)0.91440 (17.7)84 (25.4)1.625 (0.989–2.670)0.055
A573 (55.6)808 (53.4)1.0 (ref.) 322 (55.7)477 (56.0)1.0 (ref.) 251 (55.5)331 (50.0)1.0 (ref.) 
C457 (44.4)706 (46.6)1.098 (0.934–1.284)0.261256 (44.3)375 (44.0)0.989 (0.799–1.223)0.918201 (44.5)331 (50.0)1.249 (0.982–1.588)0.070
  1. GN Glomerulonephritis, CKD chronic kidney disease, ESRD end-stage renal disease, M male, F female, CI confidence interval; italic P value: statistically significant