Fig. 2

STZ increases the levels of proinflammatory cytokines in NOD/ShiLtJ mice. STZ (180 mg/kg) or vehicle was injected intraperitoneally into 10-week-old female NOD/ShiLtJ mice (n = 3 per group). Sections of parotid glands obtained 11 days after administration of STZ were stained with antibodies against interleukin (IL)-6, IL-17, and tumor necrosis factor-α (TNF-α). Representative histological features and numbers of antibody-positive cells are shown. Scale bar = 100 µm. ^*P < 0.05 and ^**P < 0.01 vs. vehicle-treated group. Data are mean ± SD