Fig. 9
From: Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular hyperpermeability
NO synthases expression in the lungs of WT sham, WT CLP and WT CLP R-954 mice. a p-eNOSser1177 immunostaining in the lungs of the WT sham, WT CLP and WT CLP R-954 groups. Scale: 50 µm (optical microscope magnification ×400). b iNOS immunostaining in the lungs of the WT sham, WT CLP and WT CLP R-954 groups. The black arrows indicate intra-alveolar macrophages marked by iNOS. Scale: 50 µm (optical microscope magnification ×400). c p-eNOSser1177 expression in relation to the immunostained total surface area, established for 10 fields selected randomly by slide, with magnification ×400 (in %). (D) iNOS expression in relation to the immunostained total surface area, established for 10 fields selected randomly by slide, with magnification ×400 (in %). WT sham: sham-operated C57BL/6J controls; WT CLP: CLP-induced septic C57BL/6J mice; WT CLP R-954: CLP-induced septic C57BL/6J mice receiving prophylactic B1R antagonist R-954. For c and d Kruskal–Wallis test followed by a Dunn’s correction. n = 7 to 10 per group. **p < 0.01; ****p < 0.0001. Results expressed in median ± IQR