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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular hyperpermeability

Fig. 6

The impact of R1B blockade on renal histological lesions due to sepsis. Histological analysis of the renal cortex 30 h after sham surgery, CLP, or CLP with R-954 antagonist. Hematoxylin–eosin staining. Magnification ×400. Scale: 50 µm. a Normal renal parenchyma. b Renal tubular cell vacuolization lesion (white arrow). c Intratubular cast (white arrow). d Desquamation lesion (white arrow). e Example combining an intratubular cast (black star) and desquamation lesion (white arrow). f Mean Kidney Injury Score for 10 fields per slide evaluated in a blinded fashion (optical microscopy, ×400 magnification). WT sham: sham-operated C57BL/6J controls; WT CLP: CLP-induced septic C57BL/6J mice; WT CLP R-954: CLP-induced septic C57BL/6J mice receiving prophylactic B1R antagonist R-954. Kruskal–Wallis test followed by a Dunn’s correction. n = 7 to 11 per group. *p < 0.05. Results expressed in median ± IQR

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