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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular hyperpermeability

Fig. 4

The role of R1B blockade in the inflammatory profile during sepsis. Determination of the serum concentration of the pro-inflammatory cytokine, IL-6, the anti-inflammatory cytokine, IL-10 and the IL-6/IL-10 ratio at H30 post-surgery in wild-type mice. n = 7 to 11 per group. WT sham: sham-operated C57BL/6J controls; WT CLP: CLP-induced septic C57BL/6J mice; WT CLP R-954: CLP-induced septic C57BL/6J mice that received prophylactic B1R antagonist R-954. Kruskal–Wallis test followed by a Dunn’s correction. *p < 0.05; **p < 0.01; ***p < 0.001. Results expressed in median ± IQR

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