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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Kinin B1 receptor: a potential therapeutic target in sepsis-induced vascular hyperpermeability

Fig. 3

Renal expression of pro-inflammatory cytokines, molecules that reflect endothelial activation and VE-cadherin. a Rt-PCR of pro-inflammatory cytokines, TNF-α, IL-1β and IL-6, normalized by GAPDH. b Rt-PCR of eNOS, iNOS, kinin B2 receptor, VEGFR1, VEGFR2 and VE-cadherin normalized by GAPDH. WT sham: sham-operated C57BL/6J controls; WT CLP: CLP-induced septic C57BL/6J mice; WT CLP R-954: CLP-induced septic C57BL/6J mice receiving prophylactic B1R antagonist R-954. Kruskal–Wallis test followed by a Dunn’s correction. *p < 0.05; **p < 0.01. Results expressed in median ± IQR

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