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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Characterization of IL-19, -20, and -24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24

Fig. 7

Schematic representation of how the IL-20 cytokine subfamily members may mediate the progression of tissue fibrosis. Our results demonstrated the increased expression of Il19, Il20, and Il24 in different renal pathologies. We have shown the role of IL-1β, TGF-β, PDGF-B, H2O2, LPS on the regulation of Il19, Il20, and Il24 expression of the PBMCs. We also demonstrated the presence of their common receptor subunit, IL-20RB on kidney epithelial cells. Moreover, we described the role of IL-20RB in the renal fibrosis. Furthermore, we revealed the effect of IL-24 on profibrotic growth factor production of renal tubular epithelial cells that may lead to activation of renal myofibroblasts

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