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Table 2 Uni- and multivariable analyses of (a) cancer-specific and (b) overall survival in non-irradiated CRCs

From: Association between local immune cell infiltration, mismatch repair status and systemic inflammatory response in colorectal cancer

Variable

Univariable

Multivariable

HR (95%CI)

p

HR (95%CI)

p

(a) Cancer survivala

 Female gender

1.17 (0.74–1.83)

0.503

  

 Right colon

1.00 (Reference)

 

1.00 (Reference)

 

 Left colon

1.45 (0.77–2.71)

0.251

1.14 (0.60–2.17)

0.682

 Rectum

1.54 (0.88–2.70)

0.128

1.04 (0.58–1.89)

0.888

 Stage I

0.09 (0.02–0.37)

0.001

0.08 (0.02–0.33)

< 0.001

 Stage II

0.34 (0.17–0.68)

0.002

0.25 (0.12–0.51)

< 0.001

 Stage III

1.00 (Reference)

 

1.00 (Reference)

 

 Stage IV

3.08 (1.91–4.97)

<0.001

3.43 (2.02–5.84)

< 0.001

 CRP (per 10mg/l)

1.09 (1.01–1.17)

0.022

1.08 (1.00–1.15)

0.042

 Age (per 10 years)

1.24 (1.02–1.51)

0.032

1.59 (1.30–1.95)

< 0.001

(b) Overall survivalb

 Female gender

1.10 (0.78–1.54)

0.60

  

 Right colon

1.00 (Reference)

 

1.00 (Reference)

 

 Left colon

0.79 (0.49–1.28)

0.49

0.87 (0.52–1.44)

0.58

 Rectum

1.18 (0.80–1.73)

0.79

1.10 (0.73–1.64)

0.66

 Stage I

0.48 (0.28–0.81)

0.006

0.40 (0.23–0.70)

0.001

 Stage II

0.71 (0.46–1.10)

0.12

0.50 (0.32–0.80)

0.003

 Stage III

1.00 (Reference)

 

1.00 (Reference)

Reference

 Stage IV

2.40 (1.53–3.76)

< 0.001

3.13 (1.93–5.06)

< 0.001

 CRP (per 10mg/l)

1.05 (0.99–1.12)

0.096

1.08 (1.01–1.15)

0.037

 Age (per 10 years)

2.00 (1.68–2.38)

< 0.001

1.66 (1.25–2.20)

< 0.001

  1. aCRP and age were included as continuous variables in steps of 10 units. The multivariable analysis was stratified for gender. Other deaths used as competing events
  2. bCRP and age were included as continuous variables in steps of 10 units divided by 10. The multivariable analysis was stratified for gender and a time-dependent correction term for age (1.10/year, 95% CI 1.03–1.17, p=0.004) was added to account for deviation from the Cox model assumption of constant hazard ratio over time