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Table 3 Specificity and sensitivity of the detection of treatment failure based on cfHPV DNA assessment exclusively

From: Circulating HPV16 DNA may complement imaging assessment of early treatment efficacy in patients with HPV-positive oropharyngeal cancer

cfHPV16 DNA

Treatment failure (residual or metastatic disease)

No of individuals

Residual or metastatic disease

Cured

Total

Positive

5a

1b

6 (PPV, 83%)

Negative

0

60

60 (NPV, 100%)

Total

5 (sensitivity, 100%)

61 (specificity, 98%)

66

  1. NPV negative predictive value, PPV positive predictive value
  2. aPatients: 10, 19, 20, 22, 66
  3. bPatient: 29