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Table 2 Patients with incomplete radiological response 12 weeks after treatment (additional patient (29) with complete radiological response but with positive cfHPV16 DNA)

From: Circulating HPV16 DNA may complement imaging assessment of early treatment efficacy in patients with HPV-positive oropharyngeal cancer

Patient no.a

12 weeks after treatment

Subsequent (> 12 weeks)

Final result

Radiol. finding

cfHPV16 DNA

Intervention (pathology)

Radiol. finding

cfHPV16 DNA

Intervention (pathology)

1 (3)

L

NED

Cured

2 (4)

N

ND (−)

NED

Cured

3 (5)

N

NED

Cured

4 (10)

N

+

Liver

+

Biopsy (+)

Distant (liver)

5 (11)

L + N

NED

Cured

6 (17)

N

Biopsy (−)

NED

Cured

7 (19)

L

+

Tumorectomy (+)

L

+

Biopsy (+)

Local failure

8 (20)

N

+

ND (+)

Lung

+

Distant (lung)

9 (22)

N

+

ND (+)

NED

Cured

10 (24)

L

NED

Cured

11 (29)

+

NED

Cured

12 (31)

N

ND (−)

NED

Cured

13 (40)

N

NED

Cured

14 (42)

N

NED

Cured

15 (44)

N

Biopsy (−)

NED

Cured

16 (46)

N

NED

Cured

17 (48)

N

Biopsy (−)

NED

Cured

18 (53)

N

NED

Cured

19 (54)

N

Biopsy (−)

NED

Cured

20 (55)

N

Biopsy (−)

NED

Cured

21 (58)

N

NED

Cured

22 (59)

N

NED

Cured

23 (63)

N

NED

Cured

24 (66)

Nb

+

Lung

+

Distant (lung)

  1. L local residual disease, N nodal residual disease, ND nodal dissection, NED no evidence of disease
  2. aIn brackets numbers of consecutive patients as discussed in text
  3. bMediastinal nodes, radiol. finding—result of PET or MR or TK—first radiological assessment after treatment (12 weeks after treatment)