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Table 3 Effect of HOTAIR overexpression on radiosensitivity of different cancer types

From: The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

  Type of malignancy Radiosensitivity Molecular mechanism Mode of action Reference
HOTAIR overexpression Colorectal cancer Reduction MMP-2 and MMP-9 increase Promoting EMT and metastasis [97]
Pancreatic ductal carcinoma Reduction (WIF-1) decrease Promoting proliferation, inhibiting apoptosis [98]
Cervical cancer Reduction HIF-1α increase, P21 decrease Induce hypoxia and radioresistance [99, 100]