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Table 3 Effect of HOTAIR overexpression on radiosensitivity of different cancer types

From: The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

 Type of malignancyRadiosensitivityMolecular mechanismMode of actionReference
HOTAIR overexpressionColorectal cancerReductionMMP-2 and MMP-9 increasePromoting EMT and metastasis[97]
Pancreatic ductal carcinomaReduction(WIF-1) decreasePromoting proliferation, inhibiting apoptosis[98]
Cervical cancerReductionHIF-1α increase, P21 decreaseInduce hypoxia and radioresistance[99, 100]