Table 3 Effect of HOTAIR overexpression on radiosensitivity of different cancer types
From: The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
| Â | Type of malignancy | Radiosensitivity | Molecular mechanism | Mode of action | Reference |
|---|---|---|---|---|---|
HOTAIR overexpression | Colorectal cancer | Reduction | MMP-2 and MMP-9 increase | Promoting EMT and metastasis | [97] |
Pancreatic ductal carcinoma | Reduction | (WIF-1) decrease | Promoting proliferation, inhibiting apoptosis | [98] | |
Cervical cancer | Reduction | HIF-1α increase, P21 decrease | Induce hypoxia and radioresistance |