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Table 1 Relationship of HOTAIR with other non-coding RNAs and proteins

From: The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

miR ID Status Function Disease Reference
miR-148a Upstream miR-148 activity represses HOTAIR expression by interacting with the corresponding promoter region Breast cancer [73]
miR-1 Upstream miR-1 supresses expression of HOTAIR and MAPK1 activity, prohibiting cell proliferation, invasion and migration Ovarian cancer [63]
miR-214-3p Upstream miR-214-3p supresses expression of HOTAIR and MAPK1 activity Ovarian cancer [63]
miR-330-5p Upstream miR-330-5p supresses expression of HOTAIR and MAPK1 activity Ovarian cancer [63]
miR-206 Competing Up-regulates BCL-W by sponging miR-206, elevating cell proliferation rate Breast cancer [62]
miR-130a Competing HOTAIR represses miR-130a, likely in a reciprocal negative feedback loop, competition in binding to similar RISC complex Galbladder cancer [65]
miR-34a Downstream HOTAIR epigenetically supresses miR-34a, leading to up-regulation of SOX2 and cell proliferation Breast cancer [64]
miR-7 Downstream HOTAIR supresses expression of HOXD10 and subsequent target, miR-7, ultimately promoting EMT process due to up-regulation of SETDB1 and STAT3 Breast cancer [78]
miR-20a-5p Downstream HOTAIR promotes cell growth, mobility and invasiveness via supressing miR-20a-5p and consequently up-regulating HMGA2 Breast cancer [83]
miR-218 Downstream HOTAIR induces radioresistance by reducing miR-218 expression level and apoptosis Breast cancer [102]
miR-138/204/217 Downstream HOTAIR directly antagonizes this complex, ultimately overexpressing EZH2 as a target of miR-138/217 Renal cell carcinoma [84]
miR-200c Downstream HOTAIR promotes epigenetic silencing of miR-200c, Through PRC2-EZH2 complex Renal cell carcinoma [84]
miR-141 Downstream HOTAIR epigenetically inhibits miR-141 expression Glioma [56]
miR-326 Downstream Inhibit miR-326 activity Glioma [57]