Table 1 Relationship of HOTAIR with other non-coding RNAs and proteins
From: The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
miR ID | Status | Function | Disease | Reference |
|---|---|---|---|---|
miR-148a | Upstream | miR-148 activity represses HOTAIR expression by interacting with the corresponding promoter region | Breast cancer | [73] |
miR-1 | Upstream | miR-1 supresses expression of HOTAIR and MAPK1 activity, prohibiting cell proliferation, invasion and migration | Ovarian cancer | [63] |
miR-214-3p | Upstream | miR-214-3p supresses expression of HOTAIR and MAPK1 activity | Ovarian cancer | [63] |
miR-330-5p | Upstream | miR-330-5p supresses expression of HOTAIR and MAPK1 activity | Ovarian cancer | [63] |
miR-206 | Competing | Up-regulates BCL-W by sponging miR-206, elevating cell proliferation rate | Breast cancer | [62] |
miR-130a | Competing | HOTAIR represses miR-130a, likely in a reciprocal negative feedback loop, competition in binding to similar RISC complex | Galbladder cancer | [65] |
miR-34a | Downstream | HOTAIR epigenetically supresses miR-34a, leading to up-regulation of SOX2 and cell proliferation | Breast cancer | [64] |
miR-7 | Downstream | HOTAIR supresses expression of HOXD10 and subsequent target, miR-7, ultimately promoting EMT process due to up-regulation of SETDB1 and STAT3 | Breast cancer | [78] |
miR-20a-5p | Downstream | HOTAIR promotes cell growth, mobility and invasiveness via supressing miR-20a-5p and consequently up-regulating HMGA2 | Breast cancer | [83] |
miR-218 | Downstream | HOTAIR induces radioresistance by reducing miR-218 expression level and apoptosis | Breast cancer | [102] |
miR-138/204/217 | Downstream | HOTAIR directly antagonizes this complex, ultimately overexpressing EZH2 as a target of miR-138/217 | Renal cell carcinoma | [84] |
miR-200c | Downstream | HOTAIR promotes epigenetic silencing of miR-200c, Through PRC2-EZH2 complex | Renal cell carcinoma | [84] |
miR-141 | Downstream | HOTAIR epigenetically inhibits miR-141 expression | Glioma | [56] |
miR-326 | Downstream | Inhibit miR-326 activity | Glioma | [57] |