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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

Fig. 2

Schematic illustration of HOTAIR interactions with PRC2 and LSD1 complexes. To function as scaffold and platform, 5′ end of HOTAIR could epigenetically mediates interaction of PRC2 complex (including EZH2, EED, SUZ1 and different RbAp) and other accompaniment proteins with promoter region of the particular genes. Additionally, appropriate function of LSD1/CoREST/REST complex depends on the interaction with 3′ end of HOTAIR, leading to de-methylation of H3K4me2 at promoter region and suppression of the corresponding gene expression. TSS; transcription start site

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