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Table 2 20 most differentially expressed proteins in Jurkat and SUDHL5 after SAHA treatment

From: HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines

Gene symbolProtein nameFold change*
Jurkat up
RWDD2BRWD domain-containing protein 2B11.3
APOBApolipoprotein B-1009.8
APOC3Apolipoprotein C-III6.9
RETSATAll-trans-retinol 13,14-reductase3.3
FERMT2Fermitin family homolog 22.8
TUBB2ATubulin beta-2A chain2.6
MT-CO1Cytochrome c oxidase subunit 12.5
TUBB3Tubulin beta-3 chain2.3
BAG3BAG family molecular chaperone regulator 32.2
H1FXHistone H1x2.1
Jurkat down
UNGUracil-DNA glycosylase− 3.3
TTC4Tetratricopeptide repeat protein 4− 2.6
TIMM8BMitochondrial import inner membrane translocase subunit Tim8 B− 2.5
NAF1H/ACA ribonucleoprotein complex non-core subunit NAF1− 2.1
ZFAND5AN1-type zinc finger protein 5− 2.0
CD3ET-cell surface glycoprotein CD3 epsilon chain− 1.9
CD247T-cell surface glycoprotein CD3 zeta chain− 1.9
TIMM13Mitochondrial import inner membrane translocase subunit Tim13− 1.9
CCDC86Coiled-coil domain-containing protein 86− 1.9
CD3DT-cell surface glycoprotein CD3 delta chain− 1.9
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase cat. subunit beta8.2
PDCD4Programmed cell death protein 44.5
MGST3Microsomal glutathione S-transferase 33.4
HSDL2Hydroxysteroid dehydrogenase-like protein 22.5
PNKDProbable hydrolase PNKD2.3
ZNF593Zinc finger protein 5932.1
ACO1Cytoplasmic aconitate hydratase2.0
H1FXHistone H1x2.0
ITPR1Inositol 1,4,5-trisphosphate receptor type 12.0
SUDHL5 down
TYMSThymidylate synthase− 2.9
UBE2CUbiquitin-conjugating enzyme E2 C− 2.7
RRM1Ribonucleoside-diphosphate reductase large subunit− 2.6
RRM2Ribonucleoside-diphosphate reductase subunit M2− 2.2
SYF2Pre-mRNA-splicing factor SYF2− 2.1
CKS2Cyclin-dependent kinases regulatory subunit 2− 2.1
LARP4La-related protein 4− 2.1
LIMD2LIM domain-containing protein 2− 2.0
MPV17L2Mpv17-like protein 2− 2.0
RSL24D1Probable ribosome biogenesis protein RLP24− 2.0
  1. *Linear fold change