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Table 2 20 most differentially expressed proteins in Jurkat and SUDHL5 after SAHA treatment

From: HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines

Gene symbol Protein name Fold change*
Jurkat up
RWDD2B RWD domain-containing protein 2B 11.3
APOB Apolipoprotein B-100 9.8
APOC3 Apolipoprotein C-III 6.9
RETSAT All-trans-retinol 13,14-reductase 3.3
FERMT2 Fermitin family homolog 2 2.8
TUBB2A Tubulin beta-2A chain 2.6
MT-CO1 Cytochrome c oxidase subunit 1 2.5
TUBB3 Tubulin beta-3 chain 2.3
BAG3 BAG family molecular chaperone regulator 3 2.2
H1FX Histone H1x 2.1
Jurkat down
UNG Uracil-DNA glycosylase − 3.3
TTC4 Tetratricopeptide repeat protein 4 − 2.6
TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B − 2.5
NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 − 2.1
ZFAND5 AN1-type zinc finger protein 5 − 2.0
CD3E T-cell surface glycoprotein CD3 epsilon chain − 1.9
CD247 T-cell surface glycoprotein CD3 zeta chain − 1.9
TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 − 1.9
CCDC86 Coiled-coil domain-containing protein 86 − 1.9
CD3D T-cell surface glycoprotein CD3 delta chain − 1.9
SUDHL5 up
PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase cat. subunit beta 8.2
PDCD4 Programmed cell death protein 4 4.5
MGST3 Microsomal glutathione S-transferase 3 3.4
VCL Vinculin 3.1
HSDL2 Hydroxysteroid dehydrogenase-like protein 2 2.5
PNKD Probable hydrolase PNKD 2.3
ZNF593 Zinc finger protein 593 2.1
ACO1 Cytoplasmic aconitate hydratase 2.0
H1FX Histone H1x 2.0
ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 2.0
SUDHL5 down
TYMS Thymidylate synthase − 2.9
UBE2C Ubiquitin-conjugating enzyme E2 C − 2.7
RRM1 Ribonucleoside-diphosphate reductase large subunit − 2.6
RRM2 Ribonucleoside-diphosphate reductase subunit M2 − 2.2
SYF2 Pre-mRNA-splicing factor SYF2 − 2.1
CKS2 Cyclin-dependent kinases regulatory subunit 2 − 2.1
LARP4 La-related protein 4 − 2.1
LIMD2 LIM domain-containing protein 2 − 2.0
MPV17L2 Mpv17-like protein 2 − 2.0
RSL24D1 Probable ribosome biogenesis protein RLP24 − 2.0
  1. *Linear fold change