Fig. 5

Regional sensitivity (per brain region) for each region’s cumulative sensitivity threshold (i.e. the degree of atrophy each method required to detect atrophy in 80% of cases) for method 2 (a, “z-min: per data point, averaged across labels”, method 3 (b, “z-min: per label”) and method 4 (c, “z-score: per label”). The cumulative sensitivity threshold for method 2 was 88% atrophy (blue lines), for method 3 23% atrophy (red lines) and for method 4 12% atrophy (golden lines). The 80% sensitivity line is indicated by the gray dashed lines in each panel. In addition, regional specificity is plotted for each method (red dashed lines, compare also Fig. 3). All methods detected atrophy more sensitively for more pronounced degrees of atrophy