Skip to main content

Table 2 Laboratory test results and echocardiographic and angiographic characteristics

From: Real-world use of ACEI/ARB in diabetic hypertensive patients before the initial diagnosis of obstructive coronary artery disease: patient characteristics and long-term follow-up outcome

 

Before PS match

P value

After PS match

P value 

ACEI/ARB(-)

ACEI/ARB(+)

ACEI/ARB(-)

ACEI/ARB(+)

(n: 1300)

(n: 1201)

(n: 1050)

(n: 1050)

Laboratory values

 WBC, X109/L

6.8 (5.6, 8.7)

6.6 (5.5, 8.1)

<0.05

8.4 (6.3, 10.1)

7.9 (6.1, 10.2)

NS

 Neutrophil, X109/L

4.5 (3.6, 5.9)

4.4 (3.5, 5.5)

<0.05

5.9 (4.3, 7.7)

5.5 (4.0, 7.7)

NS

 Monocyte, X109/L

0.29 (0.16, 0.44)

0.27 (0.16, 0.41)

NS

0.27 (0.15, 0.42)

0.28 (0.16, 0.41)

NS

 Hemoglobin, g/L

134.5 ± 16.5

133.7 ± 15.7

<0.05

133.0 ± 18.9

132.9 ± 19.1

NS

 Hs-CRP, mg/L

2.7 (1.0, 10.4)

2.0 (0.8, 5.4)

<0.001

10.5 (2.9, 23.3)

6.1 (2.0, 16.7)

<0.05

 FBG, mmol/L

7.0 (5.8, 9.0)

6.8 (5.7, 8.3)

<0.05

7.5 (6.2, 9.3)

7.5 (6.3, 10.2)

NS

 RBG at admission, mmol/L

9.9 (7.5, 13.3)

9.7 (7.2, 12.8)

<0.05

10.8 (8.1, 14.6)

11.0 (8.7, 14.2)

NS

 Glycated hemoglobin, %

7.5 ± 1.5

7.5 ± 1.6

NS

7.7 ± 1.7

7.8 ± 1.7

NS

 ALT, U/L

19.0 (13.0, 28.0)

18.0 (13.0, 27.0)

NS

22.0 (15.0, 39.0)

21.0 (14.0, 35.0)

NS

 Creatinine, µmol/L

76.0 (65.3, 88.1)

77.8 (66.2, 90.6)

<0.05

81.8 (70.6, 96.9)

81.0 (68.7, 94.0)

NS

 eGFR, ml/min/1.73 m2

84.9 (71.4, 97.9)

82.3 (67.9, 95.3)

<0.001

79.1 (64.5, 94.5)

79.2 (64.0, 95.2)

NS

 TC, mmol/L

4.3 (3.6, 5.0)

4.2 (3.4, 4.9)

NS

4.45 ± 0.97

4.48 ± 1.12

NS

 TG, mmol/L

1.5 (1.1, 2.2)

1.5 (1.1, 2.1)

NS

1.5 (1.1, 2.0)

1.7 (1.2, 2.3)

NS

 LDL-C, mmol/L

2.4 (1.9, 2.9)

2.3 (1.8, 2.8)

< 0.001

2.6 (2.1, 3.1)

2.6 (2.0, 3.1)

NS

 HDL-C, mmol/L

1.0 (0.9, 1.2)

1.0 (0.9, 1.2)

NS

1.0 (0.9, 1.2)

1.0 (0.8, 1.2)

NS

 NT-Pro BNP,pg/ml

1621(644, 4214)

1585(521, 4548)

NS

1855(657, 4571)

1585(487, 4357)

NS

Echocardiographic values

 LVEDD, cm

5.06 ± 0.49

5.04 ± 0.48

NS

5.13 ± 0.51

5.17 ± 0.52

NS

 LVESD, cm

3.28 ± 0.57

3.21 ± 0.51

<0.05

3.53 ± 0.59

3.51 ± 0.61

<0.05

 LVEF,  %

63.93 ± 8.92

65.66 ± 7.51

<0.001

58.5 ± 9.4

60.0 ± 9.7

<0.05

 LVFS,  %

35.33 ± 6.22

36.52 ± 5.92

<0.001

31.4 ± 6.2

32.8 ± 7.2

<0.05

 LVEDV, ml

122.9 ± 28.3

122.2 ± 27.9

NS

127.5 ± 30.0

129.9 ± 31.9

NS

 LVESV, ml

41.0 (32.2, 51.2)

38.2 (32.2, 48.4)

<0.05

47.4 (38.8, 65.9)

47.4 (36.7, 62.0)

NS

 LA,cm

3.71 ± 0.43

3.74 ± 0.41

<0.05

3.76 ± 0.45

3.78 ± 0.42

NS

 E/A

0.80 (0.68, 1.00)

0.79 (0.68, 1.00)

NS

0.84 (0.69, 1.16)

0.81 (0.67, 1.16)

NS

 SV, ml

76.7 (66.5, 87.9)

79.2 (68.7, 88.9)

<0.05

70.8 (63.4, 83.7)

75.4 (65.4, 87.1)

NS

Angiography values

 Involved vessel

  Single vessel

180 (13.8)

158 (13.2)

NS

157 (15.0)

138 (13.1)

NS

  Multi-vessel/LM

1120 (86.2)

1043 (86.8)

893 (85.0)

912 (86.9)

  CTO

122 (9.4)

108 (9.0)

NS

92 (8.8)

88 (8.4)

NS

  Proximal LAD

697 (53.6)

626 (52.1)

NS

557 (53.0)

551 (52.5)

NS

  1. Data are presented as mean ± SD, IQR or n (%)
  2. WBC white blood cell count, Hs-CRP high sensitivity C reactive protein, FBG fasting blood glucose, RBG random blood glucose, ALT alanine transaminase, eGFR estimated glomerular filtration rate, TC total cholesterol, TG triglycerides; LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, NT-Pro BNP N-terminal pro-brain natriuretic peptide, LVEDD left ventricular end-diastolic diameter, LVESD left ventricular end-systolic diameter, LVEF left ventricular ejection fraction, LVFS left ventricular fraction shortening, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, LA left atrium, E/A ratio of early to late ventricular filling velocities, SV stroke volume, LM left main coronary artery, CTO chronic total occlusions, LAD left anterior descending, NS non-significant