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Table 3 Univariate cox regression analysis of overall survival and ridge regression coefficients of clinical information and drug resistance signatures in the training dataset

From: An integrated prognosis model of pharmacogenomic gene signature and clinical information for diffuse large B-cell lymphoma patients following CHOP-like chemotherapy

Clinical information Univariate analysis Coefficient
HR 95% CI p value
Age 1.03 1.01–1.04 9.56 × 10−6 0.0213
Gender (reference = female)
 Male 0.95 0.70–1.30 0.75
 Extra nodal sites number 1.43 1.25–1.63 1.38 × 10−7 0.1499
 Stage 1.52 1.32–1.75 3.15 × 10−9 0.2360
 ECOGa 1.54 1.34–1.77 1.66 × 10−9 0.2951
Drug resistance probability
 Cyclophosphamide 0.76 0.40–1.44 0.40
 Doxorubicin 3.44 1.86–6.36 7.86 × 10−5 0.8221
 Vincristine 2.41 1.31–4.41 4.48 × 10−3 0.0998
  1. aThe Eastern Cooperative Oncology Group (ECOG) performance score ranges from 0 to 3, with a higher score indicating greater impairment
  2. HR hazard ratio, 95% CI 95% confidence interval