From: The effect of smoking on biological change of recurrent breast cancer
Parameters | Univarite analysis | Multivarite analysis | ||||
---|---|---|---|---|---|---|
Hazard ratio | 95% CI | p value | Hazard ratio | 95% CI | p value | |
Age at operation (years old) | ||||||
 ≤ 60 vs > 60 | 0.878 | 0.173–3.993 | 0.865 |  |  |  |
Tumor size (cm) | ||||||
 ≤ 21.8 vs > 21.8 | 1.464 | 0.322–7.445 | 0.616 |  |  |  |
Lymph node metastasis | ||||||
 Negative vs positive | 1.619 | 0.230–7.587 | 0.581 |  |  |  |
Estrogen receptor (ER) of primary tumor | ||||||
 Negative vs positive | 0.326 | 0.072–1.661 | 0.164 |  |  |  |
Progesterone receptor (PgR) of primary tumor | ||||||
 Negative vs positive | 0.341 | 0.075–1.748 | 0.182 |  |  |  |
HER2 of primary tumor | ||||||
 Negative vs positive | 8.234 | 0.405–65.239 | 0.136 |  |  |  |
Ki67 of primary tumor | ||||||
 ≤14% vs > 14% | 0.702 | 0.154–3.581 | 0.649 |  |  |  |
Intrinsic subtype HRBC | ||||||
 No vs yes | 0.261 | 0.057–1.328 | 0.100 | 0.691 | 0.093–5.986 | 0.718 |
Intrinsic subtype HER2BC | ||||||
 No vs yes | 8.234 | 0.405–65.239 | 0.136 |  |  |  |
Intrinsic subtype TNBC | ||||||
 No vs Yes | 2.423 | 0.347–11.289 | 0.325 |  |  |  |
Chemotherapy after surgery | ||||||
 No/yes | 4.133 | 0.910–20.999 | 0.065 | 3.692 | 0.537–24.657 | 0.176 |
Endocrine therapy after surgery | ||||||
 No vs yes | 0.770 | 0.165–5.403 | 0.760 |  |  |  |
Radiation therapy after surgery | ||||||
 No vs yes | 2.279 | 0.448–10.372 | 0.297 |  |  |  |
Trastuzumab after surgery | ||||||
 No vs yes | 11.924 | 0.589–93.487 | 0.090 | 0.552 | 0.014–23.153 | 0.735 |
No-treatment after surgery | ||||||
 No vs yes | – | – | 0.245 |  |  |  |
Age at recurrence (years old) | ||||||
 ≤ 62 vs > 62 | 1.008 | 0.197–4.621 | 0.992 |  |  |  |
Recurrence site biopsied | ||||||
 Local, regional lymph node vs Distant metastasis | 8.527 | 1.114–52.010 | 0.041 | 6.962 | 0.312–73.359 | 0.178 |
Change of ER in recurrence | ||||||
 The other vs negative conversion | 2.194 | 0.116–12.967 | 0.509 |  |  |  |
Change of PgR in recurrence | ||||||
 No change vs negative conversion | 0.583 | 0.083–2.742 | 0.509 |  |  |  |
Change of HER2 in recurrence | ||||||
 No change vs positive conversion | – | – | 0.203 |  |  |  |
Change of intrinsic subtype in recurrent tumor | ||||||
 No vs yes | 1.194 | 0.063–7.080 | 0.873 |  |  |  |
Disease free survival | ||||||
 ≤ 792 vs > 792 | 0.936 | 0.177–4.486 | 0.934 |  |  |  |
Smoker | ||||||
 No vs Yes | – | – | 0.052 | – | – | 0.118 |