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Table 6 Univariate and multivariate analysis with post-recurrence survival

From: The effect of smoking on biological change of recurrent breast cancer

Parameters

Univarite analysis

Multivarite analysis

Hazard ratio

95% CI

p value

Hazard ratio

95% CI

p value

Age at operation (years old)

 ≤ 60 vs > 60

0.878

0.173–3.993

0.865

   

Tumor size (cm)

 ≤ 21.8 vs > 21.8

1.464

0.322–7.445

0.616

   

Lymph node metastasis

 Negative vs positive

1.619

0.230–7.587

0.581

   

Estrogen receptor (ER) of primary tumor

 Negative vs positive

0.326

0.072–1.661

0.164

   

Progesterone receptor (PgR) of primary tumor

 Negative vs positive

0.341

0.075–1.748

0.182

   

HER2 of primary tumor

 Negative vs positive

8.234

0.405–65.239

0.136

   

Ki67 of primary tumor

 ≤14% vs > 14%

0.702

0.154–3.581

0.649

   

Intrinsic subtype HRBC

 No vs yes

0.261

0.057–1.328

0.100

0.691

0.093–5.986

0.718

Intrinsic subtype HER2BC

 No vs yes

8.234

0.405–65.239

0.136

   

Intrinsic subtype TNBC

 No vs Yes

2.423

0.347–11.289

0.325

   

Chemotherapy after surgery

 No/yes

4.133

0.910–20.999

0.065

3.692

0.537–24.657

0.176

Endocrine therapy after surgery

 No vs yes

0.770

0.165–5.403

0.760

   

Radiation therapy after surgery

 No vs yes

2.279

0.448–10.372

0.297

   

Trastuzumab after surgery

 No vs yes

11.924

0.589–93.487

0.090

0.552

0.014–23.153

0.735

No-treatment after surgery

 No vs yes

–

–

0.245

   

Age at recurrence (years old)

 ≤ 62 vs > 62

1.008

0.197–4.621

0.992

   

Recurrence site biopsied

 Local, regional lymph node vs Distant metastasis

8.527

1.114–52.010

0.041

6.962

0.312–73.359

0.178

Change of ER in recurrence

 The other vs negative conversion

2.194

0.116–12.967

0.509

   

Change of PgR in recurrence

 No change vs negative conversion

0.583

0.083–2.742

0.509

   

Change of HER2 in recurrence

 No change vs positive conversion

–

–

0.203

   

Change of intrinsic subtype in recurrent tumor

 No vs yes

1.194

0.063–7.080

0.873

   

Disease free survival

 ≤ 792 vs > 792

0.936

0.177–4.486

0.934

   

Smoker

 No vs Yes

–

–

0.052

–

–

0.118

  1. CI confidence intervals, HER2 human epidermal growth factor receptor 2, HRBC hormone receptor positive breast cancer, HER2BC human epidermal growth factor receptor 2-enriched breast cancer, TNBC triple negative breast cancer