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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Skin wound healing triggers epigenetic modifications of histone H4

Fig. 5

Changes in histone H4 acetylation observed in epidermal healing overtime. The three graphics show the time course for the change in the acetylation pattern of histone H4 at lysines 5, 8, 12, and 16 during the wound healing. a Note that the epidermis located distant from the wound presents continuous deacetylation of histone H4K5, H4K8, and H4K16, as the healing occurs. Hyperacetylation of H4K12 is found at the distant epithelium upon complete wound closure (reepithelialization at day 9). b Analysis of the epidermis adjacent to the wound revealed the deacetylation of H4K5 and H4K8, particularly upon wound closure (Day 9, reepithelialization). Conversely, significant hyperacetylation of H4K12 occurs at day 4 and day 9. c Changes in the epithelium recovering the wound were also observed. The migratory epithelial tongue displays significant deacetylation of H4K5 on day 9. The same expression pattern was observed for H4K8. The acetylation of H4K12 was unaltered upon wound closure; however, the epithelialized wound presented increased acetylation of H4K16. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001) (data represented as mean ± SEM)

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