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Table 1 Summary of patients’ clinicopathological characteristics

From: Glandular orientation and shape determined by computational pathology could identify aggressive tumor for early colon carcinoma: a triple-center study

Variables Sub variables Total D1 D2/D3 D4
Number of patients   532 (100%) 263 (49.4%) 223 (41.9%) 46 (8.6%)
Gender Male 335 (63.0%) 162 (61.6%) 141 (63.2%) 32 (69.6%)
Female 197 (37.0%) 101 (38.4%) 82 (36.8%) 14 (30.4%)
Age, years <65 141 (29.1%) 77 (29.3%) 45 (20.2%) 19 (41.3%)
≥65 391 (70.9%) 186 (70.7%) 178 (79.8%) 27 (58.7%)
Race Asian 523 (96.4%) 257 (97.7%) 220 (98.7%) 46 (100%)
Others 9 (3.6%) 6 (2.3%) 3 (1.3%) 0 (0.0%)
Histology grade W/M** 407 (76.5%) 198 (75.3%) 172 (77.1%) 37 (80.4%)
Poorly 125 (23.5%) 65 (24.7%) 51 (22.9%) 9 (19.6%)
Tumor size <5 cm 397 (75.4%) 195 (69.5%) 169 (75.8%) 33 (71.7%)
≥5 cm 135 (24.6%) 68 (30.5%) 54 (24.2%) 13 (28.3%)
Tumor stage T1/T2 393 (73.9%) 190 (72.2%) 166 (74.4%) 37 (80.4%)
T3/T4 139 (26.1%) 73 (27.8%) 57 (25.6%) 9 (19.6%)
Manual grade low 282 (69.2%) 181 (68.8%) 156 (70.0%) 31 (67.4%)
high 164 (30.8%) 82 (31.2%) 67 (30.0%) 15 (32.6%)
Location Right 278 (52.3%) 134 (50.9%) 117 (52.5%) 27 (58.7%)
Left 254 (47.7%) 129 (49.1%) 106 (47.5%) 19 (41.3%)
MSI status MSS/MSS-L 451 (84.8%) 219 (83.3%) 194 (87.0%) 38 (82.6%)
MSI-H 81 (15.2%) 44 (16.7%) 29 (13.0%) 8 (17.4%)
Perineural invasion Yes 75 (14.1%) 36 (13.7%) 33 (14.8%) 6 (13.0%)
No 457 (85.9%) 227 (86.3%) 190 (85.2%) 40 (87.0%)
Vascular invasion Yes 68 (12.8%) 33 (12.5%) 30 (13.5%) 5 (10.9%)
No 464 (87.2%) 230 (87.5%) 193 (86.5%) 41 (89.1%)
Recurrence Yes 112 (21.1%) 58 (22.1%) 53 (23.8%) 6 (13.0%)
No 420 (78.9%) 205 (77.9%) 170 (76.2%) 40 (87.0%)
  1. W/M** well/moderately, MSI: MSI-L/H microsatellite instability—low/high, MSS microsatellite stable