Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study

Table 3 Subgroup analyses for the association between SUA trajectories and NAFLD risk

	Trajectory 1	Trajectory 2	Trajectory 3	Trajectory 4	P_trend	P_interaction
Age<60 years	1.00	1.38 (0.95–2.00)	2.03 (1.31–3.15) ^**	2.70 (1.50–4.86)^**	0.0002	0.4054
Age≥60 years	1.00	0.83 (0.35–1.94)	1.21 (0.52–2.85)	1.24 (0.45–3.42)	0.2167	0.4054
Male	1.00	0.90 (0.46–1.75)	1.22 (0.64–2.33)	1.53 (0.75–3.13)	0.0135	0.2952
Female	1.00	1.31 (0.87–1.96)	2.94 (1.61–5.38) ^**	5.59 (0.25–7.40)	0.0018	0.2952
Non- obesity	1.00	1.25 (0.80–1.95)	1.67 (1.01–2.76) ^*	1.96 (1.02–3.78)^*	0.0175	0.6230
Abdominal obesity	1.00	1.33 (0.79–2.24)	2.21 (1.23–3.97) ^**	2.94 (1.36–6.33)^**	0.0010	0.6230

All analyses were adjusted for age, sex, drinking, smoking, dietary habits, exercise, BMI, abdominal obesity, VAI, BUN, SCr, dyslipidemia, MS, diabetes, hypertension, use of antidyslipidemia medication, and eGFR, except for subgroup variables. Date are shown as OR with 95%CI
SUA serum uric acid, NAFLD non-alcoholic fatty liver disease, OR odds ratio, CI confidence interval, BMI body mass index, VAI visceral fat index, BUN blood urea nitrogen, SCr serum creatinine, eGFR estimated glomerular filtration rate, MS metabolic syndrome
^*P < 0.05, ^**P < 0.01

ISSN: 1479-5876