Table 2 Association between monocyte subsets and TLRS expression and the diagnosis of idiopathic inflammatory myopathies
Variable | Cutoff value | Area under the curve (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Likelihood ratio (+) | P |
|---|---|---|---|---|---|---|
Mean fluorescence intensity of TLR4 in non-classical monocytes (arbitrary units) | > 733.5 | 0.94 (0.88–1) | 88.37 (75.52–94.93) | 93.33 (70.18–99.66) | 13.26 | < 0.0001 |
Mean fluorescence intensity of TLR4 in intermediate monocytes (arbitrary units) | > 2023 | 0.90 (0.80–1) | 54.76 (39.93–68.78) | 93.33 (70.18–99.66) | 8.21 | < 0.0001 |
Mean fluorescence intensity of TLR4 in classical monocytes (arbitrary units) | > 967 | 0.88 (0.75–1) | 90.48 (77.93–96.23) | 86.67 (62.12–97.63) | 6.78 | < 0.0001 |
% of intermediate monocytes | > 20.6 | 0.83 (0.71–0.95) | 36.36 (23.78–51.13) | 93.3 (70.18–99.66) | 5.45 | 0.0001 |