TY - JOUR AU - Zhou, Yang AU - Zhang, Ying AU - Han, Jinming AU - Yang, Mengge AU - Zhu, Jie AU - Jin, Tao PY - 2020 DA - 2020/03/17 TI - Transitional B cells involved in autoimmunity and their impact on neuroimmunological diseases JO - Journal of Translational Medicine SP - 131 VL - 18 IS - 1 AB - Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B cell subpopulations in healthy individuals, the frequency of CD24hiCD38hi TrB cells in circulation may be altered in individuals with autoimmune diseases, such as multiple sclerosis, neuromyelitisoptica spectrum disorders, systemic lupus erythematosus, Sjögren’s syndrome, rheumatoid arthritis, systemic sclerosis, and juvenile dermatomyositis. Although TrB cells play regulatory roles under inflammatory conditions, consequences of their functional impairment vary across autoimmune diseases. Since the origin, development, and function of TrB cells, especially in humans, remain unclear and controversial, this review aimed to discuss the characteristics of TrB cells at steady state and explore their role in various immune diseases, including autoimmune rheumatic diseases and neuroimmunological diseases. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-020-02289-w DO - 10.1186/s12967-020-02289-w ID - Zhou2020 ER -