Table 3 Comparison of the performance of revised 4-variable and 9-variable CKD-EPI equations and 9-variable ANN model: internal validation
Overall | Measured GFR < 60 mL/min/1.73 m2 | Measured GFR ≥ 60 mL/min/1.73 m2 | |
|---|---|---|---|
Bias—median difference (95% CI) | |||
4-variable CKD-EPI equation | 4.67 (3.55 to 5.90) | 11.04 (9.47 to 12.32) | 0.03 (− 1.73 to 1.18) |
9-variable CKD-EPI equation | 5.00 (3.82 to 6.54) P = 0.5 | 10.95 (9.08 to 12.60) P = 0.8 | − 0.10 (− 1.54 to 2.09) P = 0.3 |
9-variable ANN | 2.77 (1.82 to 4.10) P = 0.007 | 10.54 (8.40 to 11.78) P = 0.2 | − 2.91 (− 4.60 to − 1.32) P = 0.01 |
Precision – IQR of the difference (95% CI) | |||
4-variable CKD-EPI equation | 20.11 (18.46 to 21.80) | 15.90 (13.90 to 17.87) | 21.08 (19.34 to 23.80) |
9-variable CKD-EPI equation | 18.91 (17.43 to 20.48) P = 0.05 | 16.73 (14.67 to 19.05) P = 0.3 | 21.01 (18.69 to 23.78) P = 0.9 |
9-variable ANN | 19.33 (17.77 to 21.17) P = 0.3 | 16.03 (14.15 to 17.72) P = 0.9 | 20.80 (19.19 to 22.84) P = 0.7 |
Accuracy—P30, % (95% CI) | |||
4-variable CKD-EPI equation | 75.8 (72.9 to 78.6) | 53.2 (47.9 to 58.2) | 91.5 (88.8 to 93.6) |
9-variable CKD-EPI equation | 76.6 (73.7 to 79.5) P = 0.4 | 54.6 (49.6 to 59.7) P = 0.4 | 91.9 (89.6 to 94.0) P = 0.7 |
9-variable ANN | 80.0 (77.4 to 82.7) P < 0.001 | 59.9 (54.6 to 64.9) P < 0.001 | 94.0 (91.5 to 95.9) P = 0.01 |