Fig. 8From: Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injuryRole of mitophagy in the protective effect of PD against sepsis-induced NLRP3 activation. The mice were subjected to CLP and administered vehicle, PD (30 mg/kg), or PD along with mdivi-1 (3 mg/kg). Parkin−/− mice were subjected to CLP and administered PD (30 mg/kg). The mice were sacrificed at 12 h after CLP. The expression of NLRP3, ASC and Caspase-1 was quantified by immunohistochemical analysis (×400). Scale bar: 500 μmBack to article page