Fig. 6

Role of mitophagy in the protective effect of PD against sepsis-induced apoptosis. The mice were subjected to CLP and administered vehicle, PD (30 mg/kg), or PD plus mdivi-1 (3 mg/kg). Parkin−/− mice were subjected to CLP and administered PD (30 mg/kg). The mice were sacrificed at 12 h after CLP. a The expression of Bax, Bcl-2 and cleaved caspase-3 in the kidney was assessed by western blot analysis. Quantification of b Bax, c Bcl-2 and d cleaved caspase-3. e Apoptosis in isolated RTECs was assessed by TUNEL staining. Scale bar: 100 μm. f Quantification of the number of TUNEL-positive cells per field