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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

Fig. 2

Role of Parkin in the activation of PD-induced mitophagy. a The mice were subjected to CLP, administered PD (30 mg/kg) or vehicle, and sacrificed at 12 h after CLP. Parkin levels in the mitochondrial and cytosolic fractions of renal cells were evaluated by western blot analysis. Quantification of b mitochondrial and c cytoplasmic Parkin levels. d Wild-type and Parkin−/− mice were subjected to CLP and administered PD or vehicle for 12 h. Western blot analysis of the mitochondrial markers TOM20 and TIM23 was performed. Quantification of e TOM20 and f TIM23

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