Fig. 4

Ability of vesicles to metastasize and infiltrate. Mice were treated with liposomes or leukosomes at 2 h after tMCAO. Brain sections of mice were stained at 3 h and 24 h after tMCAO challenge. Prior to injection, vesicles were stained with rhodamine (red), whereas Iba1 (green) was used to stain microglia. a, b Representative images and quantification showing the transfer and infiltration of vesicles at 3 h and 24 h after tMCAO. Scale bar, 50 μm (n = 10 per group). Values represent the mean ± SD, * and ^#P < 0.05, ** and ^##P < 0.01