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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: LincRNA-EPS in biomimetic vesicles targeting cerebral infarction promotes inflammatory resolution and neurogenesis

Fig. 2

The effect of lincRNA-EPS on the over-activation of microglia and the maintenance of the stemness of NSCs. a A scratch wound was created and microglia were treated using lipopolysaccharide (LPS), leukosomes, or lncEPS-leukosomes. Representative images and quantification showed the migration of microglia. b LPS, leukosomes, or EPS-leuko (lncEPS-leukosomes) were added to the culture. ELISA was performed to determine the levels of TNF-α, IL-1β, and IL-6 in treated microglia. c Using the same treatment as mentioned above, gene expression of relative stemness (the expression of β-action is 1), including Klf4, Oct4, and Sox2 in NSCs were analyzed by RT-PCR (n = 8 per group). Values represent the mean ± SD, * and #P < 0.05, ** and ##P < 0.01

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