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Table 5 Multivariate analysis of significant clinicopathological variables and of cytoplasmic PPARγ regarding OS in the whole cohort and in various subgroups

From: Cytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers

 

Age

pT

ER

HER2

Cytoplasmic PPARγ

Whole cohort

 p

0.00001***

0.00000007***

0.008**

0.154

0.129

 HR

1.040

3.769

0.508

1.616

1.457

N-cadherin low

 p

0.002**

0.00037***

0.015*

0.528

0.044*

 HR

1.041

3.370

0.420

1.341

1.996

N-cadherin high

 p

0.000733***

0.000032***

0.174

0.035*

0.902

 HR

1.045

6.121

0.583

3.437

1.052

Cox-1 negative

 p

0.000023***

0.000008***

0.162

0.307

0.014*

 HR

1.045

3.835

0.655

1.598

2.047

Cox-1 positive

 p

0.017*

0.017*

0.023*

0.253

0.454

 HR

1.051

3.574

0.284

1.907

0.670

Cox-2 low

 p

0.000002***

0.00008***

0.015*

0.969

0.102

 HR

1.058

3.272

0.440

0.983

1.665

Cox-2 high

 p

0.112

0.000343**

0.801

0.021*

0.545

 HR

1.027

7.681

0.867

5.369

1.427

  1. HR, hazard ratio; p, p-value
  2. In the sub-groups, the same cut-off as in Figs. 2 and 3 have been used, namely 3.5 for N-Cadherin and 7 for Cox-2. Correlations are statistically significant for p < 0.05 (*) or p < 0.01 (**), p < 0.001 (***)
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Journal of Translational Medicine

ISSN: 1479-5876

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