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Table 2 Distribution of expression of PPARγ, Cox-1 and Cox-2

From: Cytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers

 

PPARγ

Cox-1

Cox-2

Total

Nuclear

Cytoplasmic

n

262

262

262

297

285

Mean IRS ± SE

4.37 ± 0.17

0.27 ± 0.04

4.09 ± 0.17

0.34 ± 0.04

5.19 ± 0.19

IRS range

12

4

12

4

12

IRS cut-off

3.5

0.5

3.5

0.5

1.5

Number of samples with negative/low expression

111 (42.4%)

213 (81.3%)

124 (47.3%)

224 (75.4%)

36 (12.6%)

Number of samples with positive/high expression

151 (57.6%)

49 (18.7%)

138 (52.7%)

73 (24.6%)

249 (87.4%)

  1. IRS cut-offs were defined by performing a ROC-curve analysis for DFS. The cut-off of 0.5 for nuclear PPARγ and for Cox-1 stainings, related to the low expression level of both markers in our cohort, define negative and positive expressions, instead of low and high expressions sub-groups respectively