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Table 4 General recommendation strength of thiazide diuretics preventing recurrent renal stones

From: Use of thiazide diuretics for the prevention of recurrent kidney calculi: a systematic review and meta-analysis

FactorDecision making
Quality of the evidence
(The higher the quality of the evidence, the more likely a strong recommendation is warranted.)
Low
Balance of benefits versus harms and burdens
(The larger the difference between the benefits and harms, the more likely a strong recommendation is warranted. The smaller the net benefit and the lower the certainty for that benefit, the more likely a conditional recommendation is warranted.)
Benefits and harms are balanced
Values and preferences
(The greater the variability or uncertainty in values and preferences, the more likely a conditional recommendation is warranted.)
Major variability
Resource use
(The higher the costs of an intervention, that is, the more resources consumed, the more likely a conditional recommendation is warranted.)
Moderate resource-intensive
Overall recommended strengthLow ↑?