Table 3 The evidence quality for short-acting and long-acting thiazide diuretics reducing the incidence of kidney stones
Quality assessment | No of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Thiazide diuretics | Placebo in recurrent renal calculus | Relative (95% CI) | Absolute | ||
Subgroup—short-acting | ||||||||||||
3 | Randomized trials | No serious risk of bias | Serious | No serious indirectness | Seriousa,b | None | 27/98 (27.6%) | 46/101 (45.5%) | See comment | 182 fewer per 1000 (from 50 fewer to 310 fewer) | Low | Important |
48% | 192 fewer per 1000 (from 53 fewer to 326 fewer) | |||||||||||
Subgroup—long-acting | ||||||||||||
5 | Randomized trials | No serious risk of bias | Seriousa,b | No serious indirectness | Seriousa,b | None | 25/188 (13.3%) | 73/184 (39.7%) | See comment | 262 fewer per 1000 (from 179 fewer to 349 fewer) | Low | Important |
42.9% | 283 fewer per 1000 (from 193 fewer to 378 fewer) | |||||||||||